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• W3034573538 endingPage "100551" @default.
• W3034573538 startingPage "100551" @default.
• W3034573538 abstract "Pathological skin picking (excoriation) is a relatively common disorder. Although it has been hypothesized to share a similar pathophysiological basis as other obsessive-compulsive (OC) spectrum disorders, to date, little work has specifically examined the precise neurobiological mechanisms involved in excoriation. Disruption in functional circuits involving the right inferior frontal gyrus (rIFG) and supplementary motor area (SMA) may be particularly relevant to skin-picking pathology as these regions have been implicated in other OC-spectrum disorders for their roles in response inhibition and voluntary motor action, respectively. To this end, the present study examined the associations between skin-picking symptom severity and resting-state functional connectivity of the rIFG and bilateral SMA. Participants endorsing elevated symptoms of excoriation completed a self-report measure of symptom severity and resting-state functional magnetic resonance imaging scan. Results indicated that symptom severity was associated with weaker connectivity between the SMA and clusters within the orbitofrontal cortex and angular gyrus. Contrary to hypotheses, there were no effects of symptom severity on functional connectivity of the rIFG. Overall, these findings suggest that skin-picking symptom severity may be associated with disruption in higher-order motor networks contributing to deficits in top-down regulation of motor behavior." @default.
• W3034573538 created "2020-06-19" @default.
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• W3034573538 date "2020-07-01" @default.
• W3034573538 modified "2023-10-17" @default.
• W3034573538 title "Resting-state functional connectivity of supplementary motor area associated with skin-picking symptom severity" @default.
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• W3034573538 doi "https://doi.org/10.1016/j.jocrd.2020.100551" @default.
• W3034573538 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8513746" @default.
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