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- W3034598984 endingPage "33" @default.
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- W3034598984 abstract "The discovery and characterization of a network of highly conserved neuronal microexons has provided fundamental new insight into mechanisms underlying nervous system development and function, as well as an important basis for pathway convergence in autism spectrum disorder. In the past few years, considerable progress has been made in comprehensively determining the repertoires of factors that control neuronal microexons. These results have illuminated molecular mechanisms that activate the splicing of microexons, including those that control gene expression programs critical for neurogenesis, as well as synaptic protein translation and neuronal activity. Remarkably, individual disruption of specific microexons in these pathways results in autism-like phenotypes and cognitive impairment in mice. This review discusses these findings and their implications for delivering new therapeutic strategies for neurological disorders." @default.
- W3034598984 created "2020-06-19" @default.
- W3034598984 creator A5032292978 @default.
- W3034598984 creator A5088805938 @default.
- W3034598984 date "2020-12-01" @default.
- W3034598984 modified "2023-10-18" @default.
- W3034598984 title "Microexons: at the nexus of nervous system development, behaviour and autism spectrum disorder" @default.
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