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• W3034608775 startingPage "88" @default.
• W3034608775 abstract "We review three recent findings that have fundamentally altered our understanding of causative mechanisms underlying fungal-related asthma. These mechanisms may be partially independent of host inflammatory processes but are strongly dependent upon the actions of Alp1 on lung structural cells. They entail (i) bronchial epithelial sensing of Alp1; (ii) Alp1-induced airway smooth muscle (ASM) contraction; (iii) Alp1-induced airflow obstruction. Collectively, these mechanisms point to Alp1 as a new target for intervention in fungal asthma." @default.
• W3034608775 created "2020-06-19" @default.
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• W3034608775 date "2020-06-16" @default.
• W3034608775 modified "2023-09-23" @default.
• W3034608775 title "Aspergillus fumigatus Protease Alkaline Protease 1 (Alp1): A New Therapeutic Target for Fungal Asthma" @default.
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• W3034608775 doi "https://doi.org/10.3390/jof6020088" @default.
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• W3034608775 hasPublicationYear "2020" @default.
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