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• W3034612532 endingPage "104180" @default.
• W3034612532 startingPage "104180" @default.
• W3034612532 abstract "Abstract During the noncanonical deletion transcription, k nucleotides are systematically skipped/deleted after each transcribed trinucleotide producing deletion-RNAs (delRNAs). Peptides matching delRNAs either result from (a) canonical translation of delRNAs; or (b) noncanonical translation of regular transcripts along expanded codons. Only along frame (start site) (a) and (b) produce identical peptides. Here, mitochondrial mass spectrometry data analyses assume expanded codon/del-transcription with 3 + k (k from 0 to 12) nucleotides. Detected peptides map preferentially on previously identified delRNAs. More peptides were detected for k (1–12) when del-transcriptional and expanded codon translations start sites coincide (i.e. the 0th frame) than for frames +1 or +2. Hence, both (a) and (b) produced peptides identified here. Biases for frame 0 decrease for k > 2, reflecting codon/anticodon expansion limits. Further analyses find preferential pyrrolysine insertion at stop codons, suggesting Pyl-specific mitochondrial suppressor tRNAs loaded by Pyl-specific tRNA synthetases with unknown origins. Pyl biases at stops are stronger for regular than expanded codons suggesting that Pyl-tRNAs are less competitive with near-cognate tRNAs in expanded codon contexts. Statistical biases for these findings exclude that detected peptides are experimental and/or bioinformatic artefacts implying both del-transcription and expanded codons translation occur in human mitochondria." @default.
• W3034612532 created "2020-06-19" @default.
• W3034612532 creator A5044699527 @default.
• W3034612532 creator A5071401773 @default.
• W3034612532 date "2020-10-01" @default.
• W3034612532 modified "2023-10-16" @default.
• W3034612532 title "Natural pyrrolysine-biased translation of stop codons in mitochondrial peptides entirely coded by expanded codons" @default.
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• W3034612532 doi "https://doi.org/10.1016/j.biosystems.2020.104180" @default.
• W3034612532 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32534170" @default.

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