FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3034617306> ?p ?o ?g. }

• W3034617306 endingPage "1043" @default.
• W3034617306 startingPage "1031" @default.
• W3034617306 abstract "Existing approaches for infection risk stratification in kidney transplant recipients are suboptimal. Here, we aimed to develop and validate a weighted score integrating non-pathogen-specific immune parameters and clinical variables to predict the occurrence of post-transplant infectious complications. To this end, we retrospectively analyzed a single-center derivation cohort of 410 patients undergoing kidney transplantation in 2008-2013 in Madrid. Peripheral blood lymphocyte subpopulations, serum immunoglobulin and complement levels were measured at one-month post-transplant. The primary and secondary outcomes were overall and bacterial infection through month six. A point score was derived from a logistic regression model and prospectively applied on a validation cohort of 522 patients undergoing kidney transplantation at 16 centers throughout Spain in 2014-2015. The SIMPLICITY score consisted of the following variables measured at month one after transplantation: C3 level, CD4⁺ T-cell count, CD8⁺ T-cell count, IgG level, glomerular filtration rate, recipient age, and infection within the first month. The discrimination capacity in the derivation and validation cohorts was good for overall (areas under the receiver operating curve of 0.774 and 0.730) and bacterial infection (0.767 and 0.734, respectively). The cumulative incidence of overall infection significantly increased across risk categories in the derivation (low-risk 13.7%; intermediate-risk, 35.9%; high-risk 77.6%) and validation datasets (10.2%, 28.9% and 50.4%, respectively). Thus, the SIMPLICITY score, based on easily available immune parameters, allows for stratification of kidney transplant recipients at month one according to their expected risk of subsequent infection." @default.
• W3034617306 created "2020-06-19" @default.
• W3034617306 creator A5006387322 @default.
• W3034617306 creator A5012540380 @default.
• W3034617306 creator A5014891928 @default.
• W3034617306 creator A5016258231 @default.
• W3034617306 creator A5018160951 @default.
• W3034617306 creator A5028697086 @default.
• W3034617306 creator A5029171340 @default.
• W3034617306 creator A5036967265 @default.
• W3034617306 creator A5039134021 @default.
• W3034617306 creator A5041818001 @default.
• W3034617306 creator A5042405011 @default.
• W3034617306 creator A5046205617 @default.
• W3034617306 creator A5055112262 @default.
• W3034617306 creator A5056211126 @default.
• W3034617306 creator A5061076401 @default.
• W3034617306 creator A5061327414 @default.
• W3034617306 creator A5062363608 @default.
• W3034617306 creator A5066044288 @default.
• W3034617306 creator A5066491567 @default.
• W3034617306 creator A5068810672 @default.
• W3034617306 creator A5069183734 @default.
• W3034617306 creator A5072787889 @default.
• W3034617306 date "2020-10-01" @default.
• W3034617306 modified "2023-10-18" @default.
• W3034617306 title "Derivation and external validation of the SIMPLICITY score as a simple immune-based risk score to predict infection in kidney transplant recipients" @default.
• W3034617306 cites W1491970318 @default.
• W3034617306 cites W1551135786 @default.
• W3034617306 cites W1582717102 @default.
• W3034617306 cites W1670276489 @default.
• W3034617306 cites W1963333652 @default.
• W3034617306 cites W1964296760 @default.
• W3034617306 cites W1973178613 @default.
• W3034617306 cites W1984856779 @default.
• W3034617306 cites W1985877668 @default.
• W3034617306 cites W1997192661 @default.
• W3034617306 cites W2037487823 @default.
• W3034617306 cites W2037736267 @default.
• W3034617306 cites W2055864845 @default.
• W3034617306 cites W2073762826 @default.
• W3034617306 cites W2079672406 @default.
• W3034617306 cites W2079776874 @default.
• W3034617306 cites W2096011212 @default.
• W3034617306 cites W2103742860 @default.
• W3034617306 cites W2116480833 @default.
• W3034617306 cites W2142261360 @default.
• W3034617306 cites W2145988176 @default.
• W3034617306 cites W2152466022 @default.
• W3034617306 cites W2152575748 @default.
• W3034617306 cites W2152722919 @default.
• W3034617306 cites W2162974025 @default.
• W3034617306 cites W2166356134 @default.
• W3034617306 cites W2166734004 @default.
• W3034617306 cites W2314567723 @default.
• W3034617306 cites W2324695930 @default.
• W3034617306 cites W2509373418 @default.
• W3034617306 cites W2524753328 @default.
• W3034617306 cites W2548147037 @default.
• W3034617306 cites W2795630644 @default.
• W3034617306 cites W2795672514 @default.
• W3034617306 cites W2897516530 @default.
• W3034617306 cites W2919855672 @default.
• W3034617306 cites W2922164643 @default.
• W3034617306 cites W56074922 @default.
• W3034617306 doi "https://doi.org/10.1016/j.kint.2020.04.054" @default.
• W3034617306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32540404" @default.
• W3034617306 hasPublicationYear "2020" @default.
• W3034617306 type Work @default.
• W3034617306 sameAs 3034617306 @default.
• W3034617306 citedByCount "5" @default.
• W3034617306 countsByYear W30346173062022 @default.
• W3034617306 countsByYear W30346173062023 @default.
• W3034617306 crossrefType "journal-article" @default.
• W3034617306 hasAuthorship W3034617306A5006387322 @default.
• W3034617306 hasAuthorship W3034617306A5012540380 @default.
• W3034617306 hasAuthorship W3034617306A5014891928 @default.
• W3034617306 hasAuthorship W3034617306A5016258231 @default.
• W3034617306 hasAuthorship W3034617306A5018160951 @default.
• W3034617306 hasAuthorship W3034617306A5028697086 @default.
• W3034617306 hasAuthorship W3034617306A5029171340 @default.
• W3034617306 hasAuthorship W3034617306A5036967265 @default.
• W3034617306 hasAuthorship W3034617306A5039134021 @default.
• W3034617306 hasAuthorship W3034617306A5041818001 @default.
• W3034617306 hasAuthorship W3034617306A5042405011 @default.
• W3034617306 hasAuthorship W3034617306A5046205617 @default.
• W3034617306 hasAuthorship W3034617306A5055112262 @default.
• W3034617306 hasAuthorship W3034617306A5056211126 @default.
• W3034617306 hasAuthorship W3034617306A5061076401 @default.
• W3034617306 hasAuthorship W3034617306A5061327414 @default.
• W3034617306 hasAuthorship W3034617306A5062363608 @default.
• W3034617306 hasAuthorship W3034617306A5066044288 @default.
• W3034617306 hasAuthorship W3034617306A5066491567 @default.
• W3034617306 hasAuthorship W3034617306A5068810672 @default.
• W3034617306 hasAuthorship W3034617306A5069183734 @default.
• W3034617306 hasAuthorship W3034617306A5072787889 @default.
• W3034617306 hasBestOaLocation W30346173062 @default.
• W3034617306 hasConcept C111472728 @default.

• next