Matches in SemOpenAlex for { <https://semopenalex.org/work/W3034626384> ?p ?o ?g. }
- W3034626384 abstract "Abstract Brain calcification (calcium phosphate mineral formation) has been reported in the past 100 years in the brains of Alzheimer’s disease (AD) patients. However, the association between calcification and AD, the triggers for calcification, and its role within the disease are not clear. On the other hand, hyperphosphorylated tau protein (pTau) tangles have been widely studied and recognized as an essential factor in developing AD. In this work, calcification in the brains of AD patients is characterized by advanced electron microscopy and fluorescence microscopy. Results are then compared to samples from cognitively healthy, age-matched donors, and the colocalization of calcification and pTau is investigated. Here, we show that AD patients’ brains present microcalcification associated with the neural cell nuclei and cell projections, and that these are strongly related to the presence of pTau. The link between microcalcification and pTau suggests a potential new mechanism of brain cell damage. Together with the formation of amyloid plaques and neurofibrillary tangles, microcalcification in neuronal cells adds to a better understanding of the pathology of AD. Finally, the presence of microcalcification in the neuronal cells of AD patients may assist in AD diagnosis, and may open new avenues for developing intervention strategies based on inhibition of calcification." @default.
- W3034626384 created "2020-06-19" @default.
- W3034626384 creator A5001546446 @default.
- W3034626384 creator A5009432106 @default.
- W3034626384 creator A5019297305 @default.
- W3034626384 creator A5073152320 @default.
- W3034626384 creator A5083825280 @default.
- W3034626384 date "2020-06-15" @default.
- W3034626384 modified "2023-09-30" @default.
- W3034626384 title "Association of cellular and subcellular calcification with phosphorylated tau in the brains of Alzheimer’s disease patients" @default.
- W3034626384 cites W1958464556 @default.
- W3034626384 cites W1972371984 @default.
- W3034626384 cites W1992716122 @default.
- W3034626384 cites W1994703716 @default.
- W3034626384 cites W2011634611 @default.
- W3034626384 cites W2025627647 @default.
- W3034626384 cites W2028588822 @default.
- W3034626384 cites W2043396974 @default.
- W3034626384 cites W2051970525 @default.
- W3034626384 cites W2052742260 @default.
- W3034626384 cites W2071203165 @default.
- W3034626384 cites W2072003666 @default.
- W3034626384 cites W2073343422 @default.
- W3034626384 cites W2083422851 @default.
- W3034626384 cites W2103913931 @default.
- W3034626384 cites W2120316106 @default.
- W3034626384 cites W2122320288 @default.
- W3034626384 cites W2125985978 @default.
- W3034626384 cites W2126961409 @default.
- W3034626384 cites W2153323361 @default.
- W3034626384 cites W2164827816 @default.
- W3034626384 cites W2226786300 @default.
- W3034626384 cites W2306625517 @default.
- W3034626384 cites W2559380250 @default.
- W3034626384 cites W2786084903 @default.
- W3034626384 cites W2888559669 @default.
- W3034626384 cites W2900348123 @default.
- W3034626384 cites W2923319164 @default.
- W3034626384 cites W2959431913 @default.
- W3034626384 cites W2988310131 @default.
- W3034626384 cites W2989855650 @default.
- W3034626384 cites W2995252331 @default.
- W3034626384 cites W3012272172 @default.
- W3034626384 cites W3037849083 @default.
- W3034626384 cites W4235875658 @default.
- W3034626384 cites W4244124667 @default.
- W3034626384 cites W596124110 @default.
- W3034626384 doi "https://doi.org/10.1101/2020.06.15.148353" @default.
- W3034626384 hasPublicationYear "2020" @default.
- W3034626384 type Work @default.
- W3034626384 sameAs 3034626384 @default.
- W3034626384 citedByCount "1" @default.
- W3034626384 countsByYear W30346263842023 @default.
- W3034626384 crossrefType "posted-content" @default.
- W3034626384 hasAuthorship W3034626384A5001546446 @default.
- W3034626384 hasAuthorship W3034626384A5009432106 @default.
- W3034626384 hasAuthorship W3034626384A5019297305 @default.
- W3034626384 hasAuthorship W3034626384A5073152320 @default.
- W3034626384 hasAuthorship W3034626384A5083825280 @default.
- W3034626384 hasBestOaLocation W30346263841 @default.
- W3034626384 hasConcept C121608353 @default.
- W3034626384 hasConcept C126322002 @default.
- W3034626384 hasConcept C142724271 @default.
- W3034626384 hasConcept C169760540 @default.
- W3034626384 hasConcept C185592680 @default.
- W3034626384 hasConcept C2779134260 @default.
- W3034626384 hasConcept C2780309369 @default.
- W3034626384 hasConcept C2780472235 @default.
- W3034626384 hasConcept C2781129008 @default.
- W3034626384 hasConcept C40209533 @default.
- W3034626384 hasConcept C502032728 @default.
- W3034626384 hasConcept C530470458 @default.
- W3034626384 hasConcept C71924100 @default.
- W3034626384 hasConcept C86803240 @default.
- W3034626384 hasConceptScore W3034626384C121608353 @default.
- W3034626384 hasConceptScore W3034626384C126322002 @default.
- W3034626384 hasConceptScore W3034626384C142724271 @default.
- W3034626384 hasConceptScore W3034626384C169760540 @default.
- W3034626384 hasConceptScore W3034626384C185592680 @default.
- W3034626384 hasConceptScore W3034626384C2779134260 @default.
- W3034626384 hasConceptScore W3034626384C2780309369 @default.
- W3034626384 hasConceptScore W3034626384C2780472235 @default.
- W3034626384 hasConceptScore W3034626384C2781129008 @default.
- W3034626384 hasConceptScore W3034626384C40209533 @default.
- W3034626384 hasConceptScore W3034626384C502032728 @default.
- W3034626384 hasConceptScore W3034626384C530470458 @default.
- W3034626384 hasConceptScore W3034626384C71924100 @default.
- W3034626384 hasConceptScore W3034626384C86803240 @default.
- W3034626384 hasLocation W30346263841 @default.
- W3034626384 hasOpenAccess W3034626384 @default.
- W3034626384 hasPrimaryLocation W30346263841 @default.
- W3034626384 hasRelatedWork W2075360498 @default.
- W3034626384 hasRelatedWork W2316678102 @default.
- W3034626384 hasRelatedWork W2353487352 @default.
- W3034626384 hasRelatedWork W2371557736 @default.
- W3034626384 hasRelatedWork W2382258973 @default.
- W3034626384 hasRelatedWork W2389632774 @default.
- W3034626384 hasRelatedWork W2748952813 @default.
- W3034626384 hasRelatedWork W2892147993 @default.
- W3034626384 hasRelatedWork W2899084033 @default.