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- W3034698584 abstract "Abstract Photodynamic therapy (PDT), which utilizes light excited photosensitizers (PSs) to generate reactive oxygen species (ROS) and consequently ablate cancer cells or diseased tissue, has attracted a great deal of attention in the last decades due to its unique advantages. In order to further enhance PDT effect, PSs are functionalized to target specific sub‐cellular organelles, but most PSs cannot target nucleolus, which is demonstrated as a more efficient and ideal site for cancer treatment. Here, an effective carbon dots (C‐dots) photosensitizer with intrinsic nucleolus‐targeting capability, for the first time, is synthesized, characterized, and employed for in vitro and in vivo image‐guided photodynamic anticancer therapy with enhanced treatment performance at a low dose of PS and light irradiation. The C‐dots possess high ROS generation efficiency and fluorescence quantum yield, excellent in vitro and in vivo biocompatibility, and rapid renal clearance, endowing it with a great potential for future translational research." @default.
- W3034698584 created "2020-06-19" @default.
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- W3034698584 date "2020-06-16" @default.
- W3034698584 modified "2023-10-13" @default.
- W3034698584 title "Nucleolus‐Targeted Photodynamic Anticancer Therapy Using Renal‐Clearable Carbon Dots" @default.
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- W3034698584 doi "https://doi.org/10.1002/adhm.202000607" @default.
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