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- W3034704534 endingPage "1460" @default.
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- W3034704534 abstract "The aim of this study is to evaluate the anti-obesity, anti-hyperglycaemic, analgesic and antipyretic activities of Globularia alypum (GA).GA methanol and water extracts (GAME, GAWE) were administered to high-fat-high-glucose diet (HFFD) rats.This study showed that GAME exhibited the highest antioxidant, anti-α-amylase and anti-lipase activities, with half inhibitory concentration (IC50) values 0.067, 1.05 and 2.97 mg/ml respectively. In HFFD rats, the administration of GAME inhibited lipase activity by 36, 37 and 30% in the intestine, pancreas and serum, respectively, reduced body weight by 17.7% and modulated lipid profile. In addition, administration of GAME to HFFD-rats decreased α-amylase activity, improved glucose level and protected liver function. Furthermore, the administration of GA extracts to rats revealed antipyretic (reduction in writhing by 64%) and analgesic (decrease of temperature by 1.11 °C) activities.This study showed that GA extracts exhibited an anti-obesity, anti-hyperglycaemia, anti-pyretic and analgesic activities." @default.
- W3034704534 created "2020-06-19" @default.
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- W3034704534 date "2020-06-13" @default.
- W3034704534 modified "2023-10-18" @default.
- W3034704534 title "Anti-obesity, anti-hyperglycaemic, anti-antipyretic and analgesic activities of <i>Globularia alypum</i> extracts" @default.
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- W3034704534 doi "https://doi.org/10.1080/13813455.2020.1773865" @default.
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