Matches in SemOpenAlex for { <https://semopenalex.org/work/W3034706273> ?p ?o ?g. }
- W3034706273 endingPage "470" @default.
- W3034706273 startingPage "470" @default.
- W3034706273 abstract "The four serotypes of dengue virus are the most widespread causes of arboviral disease, currently placing half of the human population at risk of infection. Pre-existing immunity to one dengue virus serotype can predispose to severe disease following secondary infection with a different serotype. The phenomenon of immune enhancement has complicated vaccine development and likely explains the poor long-term safety profile of a recently licenced dengue vaccine. Therefore, alternative vaccine strategies should be considered. This review summarises studies dissecting the adaptive immune responses to dengue virus infection and (experimental) vaccination. In particular, we discuss the roles of (i) neutralising antibodies, (ii) antibodies to non-structural protein 1, and (iii) T cells in protection and pathogenesis. We also address how these findings could translate into next-generation vaccine approaches that mitigate the risk of enhanced dengue disease. Finally, we argue that the development of a safe and efficacious dengue vaccine is an attainable goal." @default.
- W3034706273 created "2020-06-19" @default.
- W3034706273 creator A5007767076 @default.
- W3034706273 creator A5066800726 @default.
- W3034706273 date "2020-06-15" @default.
- W3034706273 modified "2023-10-18" @default.
- W3034706273 title "Adaptive Immunity to Dengue Virus: Slippery Slope or Solid Ground for Rational Vaccine Design?" @default.
- W3034706273 cites W1017348960 @default.
- W3034706273 cites W1482072302 @default.
- W3034706273 cites W1508678358 @default.
- W3034706273 cites W1516520289 @default.
- W3034706273 cites W1521187251 @default.
- W3034706273 cites W1522459451 @default.
- W3034706273 cites W1545235721 @default.
- W3034706273 cites W1562504782 @default.
- W3034706273 cites W1571993997 @default.
- W3034706273 cites W1579322839 @default.
- W3034706273 cites W1580601990 @default.
- W3034706273 cites W1585923643 @default.
- W3034706273 cites W1599389506 @default.
- W3034706273 cites W1776260136 @default.
- W3034706273 cites W1777739215 @default.
- W3034706273 cites W1785111426 @default.
- W3034706273 cites W1785302422 @default.
- W3034706273 cites W1799716582 @default.
- W3034706273 cites W1802444446 @default.
- W3034706273 cites W1828066068 @default.
- W3034706273 cites W1850437202 @default.
- W3034706273 cites W1884915680 @default.
- W3034706273 cites W1885666101 @default.
- W3034706273 cites W1893326865 @default.
- W3034706273 cites W1911753321 @default.
- W3034706273 cites W1922871278 @default.
- W3034706273 cites W1929199177 @default.
- W3034706273 cites W1942194807 @default.
- W3034706273 cites W1943768242 @default.
- W3034706273 cites W1945551713 @default.
- W3034706273 cites W1961261478 @default.
- W3034706273 cites W1964953975 @default.
- W3034706273 cites W1965143249 @default.
- W3034706273 cites W1968234422 @default.
- W3034706273 cites W1969376060 @default.
- W3034706273 cites W1971875148 @default.
- W3034706273 cites W1972097918 @default.
- W3034706273 cites W1972434452 @default.
- W3034706273 cites W1972472061 @default.
- W3034706273 cites W1973587186 @default.
- W3034706273 cites W1973957719 @default.
- W3034706273 cites W1977703540 @default.
- W3034706273 cites W1978520991 @default.
- W3034706273 cites W1979016749 @default.
- W3034706273 cites W1979039327 @default.
- W3034706273 cites W1979617709 @default.
- W3034706273 cites W1980416032 @default.
- W3034706273 cites W1980835826 @default.
- W3034706273 cites W1981052336 @default.
- W3034706273 cites W1981132160 @default.
- W3034706273 cites W1983305047 @default.
- W3034706273 cites W1983816287 @default.
- W3034706273 cites W1985057723 @default.
- W3034706273 cites W1986082370 @default.
- W3034706273 cites W1986531033 @default.
- W3034706273 cites W1987702283 @default.
- W3034706273 cites W1989392875 @default.
- W3034706273 cites W1989555063 @default.
- W3034706273 cites W1989594677 @default.
- W3034706273 cites W1989767365 @default.
- W3034706273 cites W1989946260 @default.
- W3034706273 cites W1991139744 @default.
- W3034706273 cites W1992224035 @default.
- W3034706273 cites W1992644185 @default.
- W3034706273 cites W1992994792 @default.
- W3034706273 cites W1998502041 @default.
- W3034706273 cites W1998511630 @default.
- W3034706273 cites W1999329465 @default.
- W3034706273 cites W2000001441 @default.
- W3034706273 cites W2000351107 @default.
- W3034706273 cites W2000578660 @default.
- W3034706273 cites W2001568055 @default.
- W3034706273 cites W2002842630 @default.
- W3034706273 cites W2003112798 @default.
- W3034706273 cites W2004044328 @default.
- W3034706273 cites W2005243362 @default.
- W3034706273 cites W2005355109 @default.
- W3034706273 cites W2005400722 @default.
- W3034706273 cites W2005754279 @default.
- W3034706273 cites W2007739356 @default.
- W3034706273 cites W2007761741 @default.
- W3034706273 cites W2008169728 @default.
- W3034706273 cites W2009357988 @default.
- W3034706273 cites W2010992972 @default.
- W3034706273 cites W2012599139 @default.
- W3034706273 cites W2014704269 @default.
- W3034706273 cites W2015672974 @default.
- W3034706273 cites W2016266684 @default.
- W3034706273 cites W2016383576 @default.
- W3034706273 cites W2017081541 @default.
- W3034706273 cites W2017226666 @default.