Matches in SemOpenAlex for { <https://semopenalex.org/work/W3034740411> ?p ?o ?g. }
- W3034740411 abstract "Abstract Aging-related degeneration of pancreatic islet cells contributes to impaired glucose tolerance and diabetes. Endocrine cells age heterogeneously, complicating the efforts to unravel the molecular drivers underlying endocrine aging. To overcome these obstacles, we undertook single-cell RNA sequencing of pancreatic islet cells obtained from young and aged non-diabetic cynomolgus monkeys. Despite sex differences and increased transcriptional variations, aged β-cells showed increased unfolded protein response (UPR) along with the accumulation of protein aggregates. We observed transcriptomic dysregulation of UPR components linked to canonical ATF6 and IRE1 signaling pathways, comprising adaptive UPR during pancreatic aging. Notably, we found aging-related β-cell-specific upregulation of HSP90B1, an endoplasmic reticulum-located chaperone, impeded high glucose-induced insulin secretion. Our work decodes aging-associated transcriptomic changes that underlie pancreatic islet functional decay at single-cell resolution and indicates that targeting UPR components may prevent loss of proteostasis, suggesting an avenue to delaying β-cell aging and preventing aging-related diabetes." @default.
- W3034740411 created "2020-06-19" @default.
- W3034740411 creator A5001586280 @default.
- W3034740411 creator A5003323474 @default.
- W3034740411 creator A5008582313 @default.
- W3034740411 creator A5011465604 @default.
- W3034740411 creator A5022950257 @default.
- W3034740411 creator A5023269476 @default.
- W3034740411 creator A5027353592 @default.
- W3034740411 creator A5049994616 @default.
- W3034740411 creator A5050112775 @default.
- W3034740411 creator A5050690657 @default.
- W3034740411 creator A5050914571 @default.
- W3034740411 creator A5061960579 @default.
- W3034740411 creator A5069869323 @default.
- W3034740411 creator A5073033683 @default.
- W3034740411 creator A5076711921 @default.
- W3034740411 date "2020-06-10" @default.
- W3034740411 modified "2023-10-17" @default.
- W3034740411 title "A single-cell transcriptomic atlas of primate pancreatic islet aging" @default.
- W3034740411 cites W1552235434 @default.
- W3034740411 cites W1595575404 @default.
- W3034740411 cites W1975039378 @default.
- W3034740411 cites W2017622913 @default.
- W3034740411 cites W2019669967 @default.
- W3034740411 cites W2047397124 @default.
- W3034740411 cites W2074528335 @default.
- W3034740411 cites W2079944569 @default.
- W3034740411 cites W2082432928 @default.
- W3034740411 cites W2118957830 @default.
- W3034740411 cites W2140258573 @default.
- W3034740411 cites W2140791028 @default.
- W3034740411 cites W2145869245 @default.
- W3034740411 cites W2153529164 @default.
- W3034740411 cites W2154977230 @default.
- W3034740411 cites W2158925700 @default.
- W3034740411 cites W2160260790 @default.
- W3034740411 cites W2165266278 @default.
- W3034740411 cites W2295694318 @default.
- W3034740411 cites W2302218774 @default.
- W3034740411 cites W2463988862 @default.
- W3034740411 cites W2523419694 @default.
- W3034740411 cites W2604579271 @default.
- W3034740411 cites W2758815122 @default.
- W3034740411 cites W2765081136 @default.
- W3034740411 cites W2766208502 @default.
- W3034740411 cites W2773289835 @default.
- W3034740411 cites W2780317778 @default.
- W3034740411 cites W2782858134 @default.
- W3034740411 cites W2789733259 @default.
- W3034740411 cites W2806968602 @default.
- W3034740411 cites W2884354973 @default.
- W3034740411 cites W2888046743 @default.
- W3034740411 cites W2900144939 @default.
- W3034740411 cites W2905801050 @default.
- W3034740411 cites W2913940235 @default.
- W3034740411 cites W2917754563 @default.
- W3034740411 cites W2933738638 @default.
- W3034740411 cites W2947927825 @default.
- W3034740411 cites W2948300330 @default.
- W3034740411 cites W2964032281 @default.
- W3034740411 cites W2966459681 @default.
- W3034740411 cites W2994160326 @default.
- W3034740411 cites W3004127014 @default.
- W3034740411 cites W3007560401 @default.
- W3034740411 cites W3011555918 @default.
- W3034740411 cites W3016556691 @default.
- W3034740411 cites W3022882962 @default.
- W3034740411 doi "https://doi.org/10.1093/nsr/nwaa127" @default.
- W3034740411 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8288398" @default.
- W3034740411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34691567" @default.
- W3034740411 hasPublicationYear "2020" @default.
- W3034740411 type Work @default.
- W3034740411 sameAs 3034740411 @default.
- W3034740411 citedByCount "35" @default.
- W3034740411 countsByYear W30347404112020 @default.
- W3034740411 countsByYear W30347404112021 @default.
- W3034740411 countsByYear W30347404112022 @default.
- W3034740411 countsByYear W30347404112023 @default.
- W3034740411 crossrefType "journal-article" @default.
- W3034740411 hasAuthorship W3034740411A5001586280 @default.
- W3034740411 hasAuthorship W3034740411A5003323474 @default.
- W3034740411 hasAuthorship W3034740411A5008582313 @default.
- W3034740411 hasAuthorship W3034740411A5011465604 @default.
- W3034740411 hasAuthorship W3034740411A5022950257 @default.
- W3034740411 hasAuthorship W3034740411A5023269476 @default.
- W3034740411 hasAuthorship W3034740411A5027353592 @default.
- W3034740411 hasAuthorship W3034740411A5049994616 @default.
- W3034740411 hasAuthorship W3034740411A5050112775 @default.
- W3034740411 hasAuthorship W3034740411A5050690657 @default.
- W3034740411 hasAuthorship W3034740411A5050914571 @default.
- W3034740411 hasAuthorship W3034740411A5061960579 @default.
- W3034740411 hasAuthorship W3034740411A5069869323 @default.
- W3034740411 hasAuthorship W3034740411A5073033683 @default.
- W3034740411 hasAuthorship W3034740411A5076711921 @default.
- W3034740411 hasBestOaLocation W30347404111 @default.
- W3034740411 hasConcept C103395026 @default.
- W3034740411 hasConcept C104317684 @default.
- W3034740411 hasConcept C126322002 @default.
- W3034740411 hasConcept C127561419 @default.