FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3034776875> ?p ?o ?g. }

• W3034776875 endingPage "132" @default.
• W3034776875 startingPage "121" @default.
• W3034776875 abstract "The master regulator of neuroendocrine differentiation, achaete-scute complex homolog 1 (ASCL1) defines a subgroup of lung adenocarcinoma. However, the mechanistic role of ASCL1 in lung tumorigenesis and its relation to the immune microenvironment is principally unknown. Here, the immune landscape of ASCL1-positive lung adenocarcinomas was characterized by immunohistochemistry. Furthermore, ASCL1 was transduced in mouse lung adenocarcinoma cell lines and comparative RNA-sequencing and secretome analyses were performed. The effects of ASCL1 on tumorigenesis were explored in an orthotopic syngeneic transplantation model. ASCL1-positive lung adenocarcinomas revealed lower infiltration of CD8+, CD4+, CD20+, and FOXP3+ lymphocytes and CD163+ macrophages indicating an immune desert phenotype. Ectopic ASCL1 upregulated cyclin transcript levels, stimulated cell proliferation, and enhanced tumor growth in mice. ASCL1 suppressed secretion of chemokines, including CCL20, CXCL2, CXCL10, and CXCL16, indicating effects on immune cell trafficking. In accordance with lower lymphocytes infiltration, ASCL1-positive lung adenocarcinomas demonstrated lower abundance of CXCR3-and CCR6-expressing cells. In conclusion, ASCL1 mediates its tumor-promoting effect not only through cell-autonomous signaling but also by modulating chemokine production and immune responses. These findings suggest that ASCL1-positive tumors represent a clinically relevant lung cancer entity." @default.
• W3034776875 created "2020-06-19" @default.
• W3034776875 creator A5001915657 @default.
• W3034776875 creator A5017437284 @default.
• W3034776875 creator A5020944837 @default.
• W3034776875 creator A5025698574 @default.
• W3034776875 creator A5026230156 @default.
• W3034776875 creator A5028692642 @default.
• W3034776875 creator A5028794646 @default.
• W3034776875 creator A5029528576 @default.
• W3034776875 creator A5038695535 @default.
• W3034776875 creator A5040909488 @default.
• W3034776875 creator A5047960341 @default.
• W3034776875 creator A5051370807 @default.
• W3034776875 creator A5052033876 @default.
• W3034776875 creator A5053328032 @default.
• W3034776875 creator A5057803965 @default.
• W3034776875 creator A5088395139 @default.
• W3034776875 date "2020-10-01" @default.
• W3034776875 modified "2023-10-12" @default.
• W3034776875 title "ASCL1 promotes tumor progression through cell-autonomous signaling and immune modulation in a subset of lung adenocarcinoma" @default.
• W3034776875 cites W1528164024 @default.
• W3034776875 cites W1870532304 @default.
• W3034776875 cites W1994993231 @default.
• W3034776875 cites W2038055986 @default.
• W3034776875 cites W2049674541 @default.
• W3034776875 cites W2068119757 @default.
• W3034776875 cites W2076887412 @default.
• W3034776875 cites W2103021272 @default.
• W3034776875 cites W2112727616 @default.
• W3034776875 cites W2127017743 @default.
• W3034776875 cites W2127327720 @default.
• W3034776875 cites W2150890820 @default.
• W3034776875 cites W2276790712 @default.
• W3034776875 cites W2468271545 @default.
• W3034776875 cites W2472596403 @default.
• W3034776875 cites W2479269395 @default.
• W3034776875 cites W2504915972 @default.
• W3034776875 cites W2518412322 @default.
• W3034776875 cites W2578528809 @default.
• W3034776875 cites W2606755686 @default.
• W3034776875 cites W2617691667 @default.
• W3034776875 cites W2726313690 @default.
• W3034776875 cites W2758032181 @default.
• W3034776875 cites W2781180031 @default.
• W3034776875 cites W2802415296 @default.
• W3034776875 cites W2806916167 @default.
• W3034776875 cites W2887164159 @default.
• W3034776875 cites W2895058922 @default.
• W3034776875 cites W2915645504 @default.
• W3034776875 cites W2928432651 @default.
• W3034776875 cites W2954842230 @default.
• W3034776875 cites W2981114563 @default.
• W3034776875 cites W3006378317 @default.
• W3034776875 cites W3011953068 @default.
• W3034776875 doi "https://doi.org/10.1016/j.canlet.2020.06.002" @default.
• W3034776875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32534174" @default.
• W3034776875 hasPublicationYear "2020" @default.
• W3034776875 type Work @default.
• W3034776875 sameAs 3034776875 @default.
• W3034776875 citedByCount "7" @default.
• W3034776875 countsByYear W30347768752021 @default.
• W3034776875 countsByYear W30347768752022 @default.
• W3034776875 crossrefType "journal-article" @default.
• W3034776875 hasAuthorship W3034776875A5001915657 @default.
• W3034776875 hasAuthorship W3034776875A5017437284 @default.
• W3034776875 hasAuthorship W3034776875A5020944837 @default.
• W3034776875 hasAuthorship W3034776875A5025698574 @default.
• W3034776875 hasAuthorship W3034776875A5026230156 @default.
• W3034776875 hasAuthorship W3034776875A5028692642 @default.
• W3034776875 hasAuthorship W3034776875A5028794646 @default.
• W3034776875 hasAuthorship W3034776875A5029528576 @default.
• W3034776875 hasAuthorship W3034776875A5038695535 @default.
• W3034776875 hasAuthorship W3034776875A5040909488 @default.
• W3034776875 hasAuthorship W3034776875A5047960341 @default.
• W3034776875 hasAuthorship W3034776875A5051370807 @default.
• W3034776875 hasAuthorship W3034776875A5052033876 @default.
• W3034776875 hasAuthorship W3034776875A5053328032 @default.
• W3034776875 hasAuthorship W3034776875A5057803965 @default.
• W3034776875 hasAuthorship W3034776875A5088395139 @default.
• W3034776875 hasConcept C121608353 @default.
• W3034776875 hasConcept C12823836 @default.
• W3034776875 hasConcept C13373296 @default.
• W3034776875 hasConcept C142724271 @default.
• W3034776875 hasConcept C203014093 @default.
• W3034776875 hasConcept C2781182431 @default.
• W3034776875 hasConcept C502942594 @default.
• W3034776875 hasConcept C54355233 @default.
• W3034776875 hasConcept C555283112 @default.
• W3034776875 hasConcept C71924100 @default.
• W3034776875 hasConcept C83360876 @default.
• W3034776875 hasConcept C86803240 @default.
• W3034776875 hasConcept C8891405 @default.
• W3034776875 hasConceptScore W3034776875C121608353 @default.
• W3034776875 hasConceptScore W3034776875C12823836 @default.
• W3034776875 hasConceptScore W3034776875C13373296 @default.
• W3034776875 hasConceptScore W3034776875C142724271 @default.
• W3034776875 hasConceptScore W3034776875C203014093 @default.

• next