Matches in SemOpenAlex for { <https://semopenalex.org/work/W3034777788> ?p ?o ?g. }
- W3034777788 endingPage "107757" @default.
- W3034777788 startingPage "107757" @default.
- W3034777788 abstract "The hydrophobic patch (hp), a docking pocket on cyclins of CDKs (cyclin-dependent kinases), has been thought to accommodate a single short linear motif (SLiM), the “RxL or Cy” docking motif. Here we show that hp can bind different motifs with high specificity. We identify a PxxPxF motif that is necessary for G2-cyclin Clb3 function in S. cerevisiae, and that mediates Clb3-Cdk1 phosphorylation of Ypr174c (proposed name: Cdc5 SPB anchor-Csa1) to regulate the localization of Polo kinase Cdc5. Similar motifs exist in other Clb3-Cdk1 targets. Our work completes the set of docking specificities for the four major cyclins: LP, RxL, PxxPxF, and LxF motifs for G1-, S-, G2-, and M-phase cyclins, respectively. Further, we show that variations in motifs can change their specificity for human cyclins. This diversity could provide complexity for the encoding of CDK thresholds to achieve ordered cell-cycle phosphorylation." @default.
- W3034777788 created "2020-06-19" @default.
- W3034777788 creator A5014446969 @default.
- W3034777788 creator A5016233010 @default.
- W3034777788 creator A5017134193 @default.
- W3034777788 creator A5037657345 @default.
- W3034777788 creator A5048924264 @default.
- W3034777788 creator A5051835645 @default.
- W3034777788 creator A5076532991 @default.
- W3034777788 creator A5078288183 @default.
- W3034777788 creator A5080817194 @default.
- W3034777788 creator A5084334648 @default.
- W3034777788 creator A5090178938 @default.
- W3034777788 date "2020-06-01" @default.
- W3034777788 modified "2023-10-18" @default.
- W3034777788 title "Proline-Rich Motifs Control G2-CDK Target Phosphorylation and Priming an Anchoring Protein for Polo Kinase Localization" @default.
- W3034777788 cites W1966072209 @default.
- W3034777788 cites W1970783685 @default.
- W3034777788 cites W1979213543 @default.
- W3034777788 cites W1982107179 @default.
- W3034777788 cites W1984283750 @default.
- W3034777788 cites W1984448294 @default.
- W3034777788 cites W1987134040 @default.
- W3034777788 cites W1992983658 @default.
- W3034777788 cites W1993478480 @default.
- W3034777788 cites W1999150011 @default.
- W3034777788 cites W2004377868 @default.
- W3034777788 cites W2005825070 @default.
- W3034777788 cites W2013970522 @default.
- W3034777788 cites W2019557118 @default.
- W3034777788 cites W2023333666 @default.
- W3034777788 cites W2046986600 @default.
- W3034777788 cites W2048551141 @default.
- W3034777788 cites W2051144392 @default.
- W3034777788 cites W2052553543 @default.
- W3034777788 cites W2056954863 @default.
- W3034777788 cites W2060258330 @default.
- W3034777788 cites W2064601039 @default.
- W3034777788 cites W2065593669 @default.
- W3034777788 cites W2067371805 @default.
- W3034777788 cites W2070080881 @default.
- W3034777788 cites W2073341454 @default.
- W3034777788 cites W2083731894 @default.
- W3034777788 cites W2092062544 @default.
- W3034777788 cites W2095428047 @default.
- W3034777788 cites W2102840434 @default.
- W3034777788 cites W2105131913 @default.
- W3034777788 cites W2109248504 @default.
- W3034777788 cites W2116890528 @default.
- W3034777788 cites W2119392004 @default.
- W3034777788 cites W2120881407 @default.
- W3034777788 cites W2122438523 @default.
- W3034777788 cites W2122842475 @default.
- W3034777788 cites W2123322767 @default.
- W3034777788 cites W2128705810 @default.
- W3034777788 cites W2132629607 @default.
- W3034777788 cites W2134331780 @default.
- W3034777788 cites W2139989414 @default.
- W3034777788 cites W2140660011 @default.
- W3034777788 cites W2141149624 @default.
- W3034777788 cites W2149676146 @default.
- W3034777788 cites W2150737519 @default.
- W3034777788 cites W2151527633 @default.
- W3034777788 cites W2154046032 @default.
- W3034777788 cites W2156413613 @default.
- W3034777788 cites W2156541342 @default.
- W3034777788 cites W2159610869 @default.
- W3034777788 cites W2166274256 @default.
- W3034777788 cites W2170425387 @default.
- W3034777788 cites W2501196855 @default.
- W3034777788 cites W2543985348 @default.
- W3034777788 cites W2567255685 @default.
- W3034777788 cites W2590829140 @default.
- W3034777788 cites W2594881934 @default.
- W3034777788 cites W2605190264 @default.
- W3034777788 cites W2791221265 @default.
- W3034777788 cites W2809347312 @default.
- W3034777788 cites W2899780531 @default.
- W3034777788 cites W2945104395 @default.
- W3034777788 cites W2952456576 @default.
- W3034777788 cites W2955338246 @default.
- W3034777788 doi "https://doi.org/10.1016/j.celrep.2020.107757" @default.
- W3034777788 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7301157" @default.
- W3034777788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32553169" @default.
- W3034777788 hasPublicationYear "2020" @default.
- W3034777788 type Work @default.
- W3034777788 sameAs 3034777788 @default.
- W3034777788 citedByCount "16" @default.
- W3034777788 countsByYear W30347777882020 @default.
- W3034777788 countsByYear W30347777882021 @default.
- W3034777788 countsByYear W30347777882022 @default.
- W3034777788 countsByYear W30347777882023 @default.
- W3034777788 crossrefType "journal-article" @default.
- W3034777788 hasAuthorship W3034777788A5014446969 @default.
- W3034777788 hasAuthorship W3034777788A5016233010 @default.
- W3034777788 hasAuthorship W3034777788A5017134193 @default.
- W3034777788 hasAuthorship W3034777788A5037657345 @default.
- W3034777788 hasAuthorship W3034777788A5048924264 @default.