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• W3034797925 abstract "Tryptophan metabolites have immunomodulatory functions, suggesting possible roles in cancer immunity.Plasma tryptophan metabolites were measured using liquid chromatography/mass spectrometry before immune checkpoint inhibitors (ICIs) in patients with non-small cell lung cancer (NSCLC).The 19 patients with NSCLC had significantly lower levels of tryptophan (p = 0.002) and xanthurenic acid (p = 0.032), and a significantly higher level of 3-hydroxyanthranilic acid (3-HAA) (p = 0.028) compared with the 10 healthy volunteers. The patients achieving objective responses had significantly lower levels of 3-HAA than those who did not (p = 0.045). Receiver operating characteristic analyses determined that the cutoff value of 3-HAA for objective response was 35.4 pmol/mL (sensitivity: 87.5% and specificity: 83.3%). The patients with 3-HAA < 35.4 pmol/mL had significantly longer median progression-free survival (7.0 months) than those without (1.6 months, p = 0.022).Tryptophan metabolites may have a potential for predicting the efficacy of ICIs.University Hospital Medical Information Network Clinical Trial Registry 000026140." @default.
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• W3034797925 date "2020-06-12" @default.
• W3034797925 modified "2023-10-15" @default.
• W3034797925 title "Comprehensive assessment of multiple tryptophan metabolites as potential biomarkers for immune checkpoint inhibitors in patients with non-small cell lung cancer" @default.
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• W3034797925 doi "https://doi.org/10.1007/s12094-020-02421-8" @default.
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