FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3034813408> ?p ?o ?g. }

• W3034813408 endingPage "273" @default.
• W3034813408 startingPage "262" @default.
• W3034813408 abstract "Background: The anticancer effects of Phyllanthus amarus extract on various cancer cells have been investigated, however, the effects of its major constituents on HCT116 human colorectal cancer cells have not been reported. Objective: In the present study, we investigated the cytotoxic effect of 80% ethanol extract of P. amarus and its marker constituents (phyllanthin, hypophyllanthin, gallic acid, niranthin, greraniin, phyltetralin, isolintetralin, corilagin and ellagic acid) on HCT116 and their underlying mechanisms of action. Methods: Their antiproliferative and apoptotic effects on HCT 116 were performed using MTT assay and flow cytometric analysis, respectively, while caspases 3/7, 8 and 9 activities were examined using the colorimetric method. The expression of cleaved poly ADP ribose polymerase enzyme (PARP) and cytochrome c proteins was investigated by the immune-blot technique. Results and Discussion: HPLC and LC-MS/MS analyses demonstrated that the extract contained mainly lignans and polyphenols. The plant samples markedly suppressed the growth and expansion of HCT116 cells in a concentration- and time-dependent manner with no toxicity against normal human fibroblast CCD18 Co. P. amarus extract, phyllanthin and gallic acid induced mode of cell death primarily through apoptosis as confirmed by the exteriorization of phosphatidylserine. Caspases 3/7, 8, and 9 activities increased in a concentration-dependent manner following 24h treatment. The expressions of cleaved PARP (Asp 214) and cytochrome c were markedly upregulated. Conclusion: P. amarus extract, phyllanthin and gallic acid exhibited an apoptotic effect on HCT116 cells through the caspases-dependent pathway." @default.
• W3034813408 created "2020-06-19" @default.
• W3034813408 creator A5004105099 @default.
• W3034813408 creator A5025801018 @default.
• W3034813408 creator A5076395892 @default.
• W3034813408 creator A5076444534 @default.
• W3034813408 creator A5085692285 @default.
• W3034813408 date "2021-02-01" @default.
• W3034813408 modified "2023-09-23" @default.
• W3034813408 title "Lignans and Polyphenols of Phyllanthus amarus Schumach and Thonn Induce Apoptosis in HCT116 Human Colon Cancer Cells through Caspases-Dependent Pathway" @default.
• W3034813408 cites W1890121728 @default.
• W3034813408 cites W1980924993 @default.
• W3034813408 cites W2008757142 @default.
• W3034813408 cites W2008885242 @default.
• W3034813408 cites W2019406468 @default.
• W3034813408 cites W2023691212 @default.
• W3034813408 cites W2039082329 @default.
• W3034813408 cites W2045230446 @default.
• W3034813408 cites W2045991390 @default.
• W3034813408 cites W2069465836 @default.
• W3034813408 cites W2078251012 @default.
• W3034813408 cites W2095506424 @default.
• W3034813408 cites W2096956453 @default.
• W3034813408 cites W2107060734 @default.
• W3034813408 cites W2107588151 @default.
• W3034813408 cites W2110727662 @default.
• W3034813408 cites W2114266096 @default.
• W3034813408 cites W2120939161 @default.
• W3034813408 cites W2122560536 @default.
• W3034813408 cites W2129770376 @default.
• W3034813408 cites W2136460234 @default.
• W3034813408 cites W2170199223 @default.
• W3034813408 cites W2346771607 @default.
• W3034813408 cites W2417264979 @default.
• W3034813408 cites W2594848823 @default.
• W3034813408 cites W2782252352 @default.
• W3034813408 cites W626649172 @default.
• W3034813408 doi "https://doi.org/10.2174/1389201021666200612173029" @default.
• W3034813408 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32532192" @default.
• W3034813408 hasPublicationYear "2021" @default.
• W3034813408 type Work @default.
• W3034813408 sameAs 3034813408 @default.
• W3034813408 citedByCount "5" @default.
• W3034813408 countsByYear W30348134082022 @default.
• W3034813408 countsByYear W30348134082023 @default.
• W3034813408 crossrefType "journal-article" @default.
• W3034813408 hasAuthorship W3034813408A5004105099 @default.
• W3034813408 hasAuthorship W3034813408A5025801018 @default.
• W3034813408 hasAuthorship W3034813408A5076395892 @default.
• W3034813408 hasAuthorship W3034813408A5076444534 @default.
• W3034813408 hasAuthorship W3034813408A5085692285 @default.
• W3034813408 hasConcept C109316439 @default.
• W3034813408 hasConcept C121608353 @default.
• W3034813408 hasConcept C181199279 @default.
• W3034813408 hasConcept C182979987 @default.
• W3034813408 hasConcept C185592680 @default.
• W3034813408 hasConcept C190283241 @default.
• W3034813408 hasConcept C202751555 @default.
• W3034813408 hasConcept C2778004101 @default.
• W3034813408 hasConcept C2778362808 @default.
• W3034813408 hasConcept C2780783641 @default.
• W3034813408 hasConcept C2781464872 @default.
• W3034813408 hasConcept C29311851 @default.
• W3034813408 hasConcept C31573885 @default.
• W3034813408 hasConcept C54355233 @default.
• W3034813408 hasConcept C55493867 @default.
• W3034813408 hasConcept C556039675 @default.
• W3034813408 hasConcept C70899900 @default.
• W3034813408 hasConcept C71924100 @default.
• W3034813408 hasConcept C82381507 @default.
• W3034813408 hasConcept C86803240 @default.
• W3034813408 hasConcept C96232424 @default.
• W3034813408 hasConcept C98274493 @default.
• W3034813408 hasConcept C98424977 @default.
• W3034813408 hasConceptScore W3034813408C109316439 @default.
• W3034813408 hasConceptScore W3034813408C121608353 @default.
• W3034813408 hasConceptScore W3034813408C181199279 @default.
• W3034813408 hasConceptScore W3034813408C182979987 @default.
• W3034813408 hasConceptScore W3034813408C185592680 @default.
• W3034813408 hasConceptScore W3034813408C190283241 @default.
• W3034813408 hasConceptScore W3034813408C202751555 @default.
• W3034813408 hasConceptScore W3034813408C2778004101 @default.
• W3034813408 hasConceptScore W3034813408C2778362808 @default.
• W3034813408 hasConceptScore W3034813408C2780783641 @default.
• W3034813408 hasConceptScore W3034813408C2781464872 @default.
• W3034813408 hasConceptScore W3034813408C29311851 @default.
• W3034813408 hasConceptScore W3034813408C31573885 @default.
• W3034813408 hasConceptScore W3034813408C54355233 @default.
• W3034813408 hasConceptScore W3034813408C55493867 @default.
• W3034813408 hasConceptScore W3034813408C556039675 @default.
• W3034813408 hasConceptScore W3034813408C70899900 @default.
• W3034813408 hasConceptScore W3034813408C71924100 @default.
• W3034813408 hasConceptScore W3034813408C82381507 @default.
• W3034813408 hasConceptScore W3034813408C86803240 @default.
• W3034813408 hasConceptScore W3034813408C96232424 @default.
• W3034813408 hasConceptScore W3034813408C98274493 @default.
• W3034813408 hasConceptScore W3034813408C98424977 @default.
• W3034813408 hasFunder F4320322740 @default.

• next