FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3034886481> ?p ?o ?g. }

• W3034886481 endingPage "740" @default.
• W3034886481 startingPage "731" @default.
• W3034886481 abstract "This study emphasized on the neuroprotective properties of bitter leaf alkaloid-rich extract (BLAE) using transgenic fruit fly (Drosophila melanogaster [D. melanogaster]) model and scopolamine-induced amnesia rats. In vitro antioxidant properties and modulatory effects on key neuronal enzymes were carried out. Thereafter, fruit flies expressing human amyloid precursor protein (hAPP) and BACE-1 genes were treated with BLAE for 7 d to determine survival rate, BACE-1, acetylthiocholine (AChE), glutathione-S-transferase (GST), and catalase activities. Also, the aftermath of the BLAE on the neuronal activities of AChE, butyrylcholine (BChE), monoamine oxidase (MAO), angiotensin-I converting enzyme (ACE), ATP diphosphohydrolase (ATPdase), and ADPdase, catalase, superoxide dismutase (SOD), plus TBARS, and nitric oxide (NO) content in rats treated with scopolamine (1 mg/kg. bwt. i.p.) was evaluated. In addition, the alkaloid characterization for constituent BLAE was determined. The outcomes proved that BLAE displayed antioxidant properties and inhibit activities of AChE, BChE, MAO, ACE, ATPdase, and ADPdase in vitro. Furthermore, transgenic flies treated with the BLAE exhibited significant levels of amelioration on survival rate and activities of BACE-1, AChE, GST, and catalase. In scopolamine-treated rats, AChE, BChE, MAO and NTPdases activities, and antioxidant status were upturned in rats pretreated with BLAE. This study disclosed the neuroprotective property of BLAE, which could be related to its alkaloid constituent, thereby making it a good candidate to explore as curative nutraceutical agent for cognitive impairments and affiliated diseases such as AD." @default.
• W3034886481 created "2020-06-19" @default.
• W3034886481 creator A5026898000 @default.
• W3034886481 creator A5030437818 @default.
• W3034886481 creator A5032519280 @default.
• W3034886481 creator A5036515858 @default.
• W3034886481 creator A5062749709 @default.
• W3034886481 date "2020-06-16" @default.
• W3034886481 modified "2023-09-26" @default.
• W3034886481 title "Characterization and neuroprotective properties of alkaloid extract of <i>Vernonia amygdalina</i> Delile in experimental models of Alzheimer’s disease" @default.
• W3034886481 cites W1536923222 @default.
• W3034886481 cites W1736389176 @default.
• W3034886481 cites W1845040158 @default.
• W3034886481 cites W191630185 @default.
• W3034886481 cites W1949061541 @default.
• W3034886481 cites W1973591193 @default.
• W3034886481 cites W1973755223 @default.
• W3034886481 cites W1976696638 @default.
• W3034886481 cites W1980299591 @default.
• W3034886481 cites W1983310681 @default.
• W3034886481 cites W1983475981 @default.
• W3034886481 cites W1984227891 @default.
• W3034886481 cites W1987000855 @default.
• W3034886481 cites W1988396798 @default.
• W3034886481 cites W1989894962 @default.
• W3034886481 cites W1990802251 @default.
• W3034886481 cites W1995947856 @default.
• W3034886481 cites W2002946658 @default.
• W3034886481 cites W2004916147 @default.
• W3034886481 cites W2006881798 @default.
• W3034886481 cites W2007649442 @default.
• W3034886481 cites W2010110703 @default.
• W3034886481 cites W2010499668 @default.
• W3034886481 cites W2012991711 @default.
• W3034886481 cites W2017587618 @default.
• W3034886481 cites W2017606063 @default.
• W3034886481 cites W2017889639 @default.
• W3034886481 cites W2025022665 @default.
• W3034886481 cites W2030439107 @default.
• W3034886481 cites W2032726478 @default.
• W3034886481 cites W2034920555 @default.
• W3034886481 cites W2036915317 @default.
• W3034886481 cites W2037241533 @default.
• W3034886481 cites W2039222352 @default.
• W3034886481 cites W2041317303 @default.
• W3034886481 cites W2041573170 @default.
• W3034886481 cites W2045251148 @default.
• W3034886481 cites W2045294258 @default.
• W3034886481 cites W2053552819 @default.
• W3034886481 cites W2053696585 @default.
• W3034886481 cites W2055065148 @default.
• W3034886481 cites W2058132287 @default.
• W3034886481 cites W2064004368 @default.
• W3034886481 cites W2066028265 @default.
• W3034886481 cites W2076654662 @default.
• W3034886481 cites W2082114400 @default.
• W3034886481 cites W2090144237 @default.
• W3034886481 cites W2091548061 @default.
• W3034886481 cites W2093001495 @default.
• W3034886481 cites W2096795975 @default.
• W3034886481 cites W2099292604 @default.
• W3034886481 cites W2117230359 @default.
• W3034886481 cites W2126399705 @default.
• W3034886481 cites W2128126778 @default.
• W3034886481 cites W2130015016 @default.
• W3034886481 cites W2139066688 @default.
• W3034886481 cites W2153435210 @default.
• W3034886481 cites W2153767421 @default.
• W3034886481 cites W2160763183 @default.
• W3034886481 cites W2268556801 @default.
• W3034886481 cites W2290984097 @default.
• W3034886481 cites W2293925129 @default.
• W3034886481 cites W2378640070 @default.
• W3034886481 cites W2396494944 @default.
• W3034886481 cites W2413606534 @default.
• W3034886481 cites W2474499768 @default.
• W3034886481 cites W2488675223 @default.
• W3034886481 cites W2537066862 @default.
• W3034886481 cites W2547907108 @default.
• W3034886481 cites W2575530924 @default.
• W3034886481 cites W2578838809 @default.
• W3034886481 cites W2586627287 @default.
• W3034886481 cites W2609933898 @default.
• W3034886481 cites W2744427011 @default.
• W3034886481 cites W2789861678 @default.
• W3034886481 cites W2793455268 @default.
• W3034886481 cites W2883986681 @default.
• W3034886481 cites W2898250958 @default.
• W3034886481 cites W2944527817 @default.
• W3034886481 cites W2971964331 @default.
• W3034886481 cites W2997152294 @default.
• W3034886481 cites W32239657 @default.
• W3034886481 cites W4293247451 @default.
• W3034886481 doi "https://doi.org/10.1080/01480545.2020.1773845" @default.
• W3034886481 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32543989" @default.
• W3034886481 hasPublicationYear "2020" @default.
• W3034886481 type Work @default.
• W3034886481 sameAs 3034886481 @default.

• next