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- W3034936371 endingPage "101947" @default.
- W3034936371 startingPage "101947" @default.
- W3034936371 abstract "The mechanisms underlying Bacille Calmette-Guérin (BCG) vaccine's protective effects against tuberculosis (TB) are incompletely understood but are proposed to involve a predominantly cell-mediated process. However, there is increasing evidence for the involvement of antibodies in the control of Mycobacteria tuberculosis and in the immune response to BCG.We did a systematic review of studies investigating anti-BCG antibodies in individuals with active or latent TB, and in the response to BCG vaccination.Of 1417 articles screened, 70 were relevant, comprising 52 investigating anti-BCG antibodies in TB and 18 investigating the anti-BCG antibody response to BCG-vaccination. Individuals with active TB have higher levels of anti-BCG antibodies compared with individuals with latent TB or healthy individuals. Antibodies to BCG are present after BCG vaccination. There is some evidence for the in utero transfer of maternal anti-BCG antibodies to infants.BCG vaccination induces a humoral response. Antibodies targeted against BCG and its antigens may play a role in protection against active TB." @default.
- W3034936371 created "2020-06-19" @default.
- W3034936371 creator A5025034273 @default.
- W3034936371 creator A5072329346 @default.
- W3034936371 creator A5079507328 @default.
- W3034936371 date "2021-12-01" @default.
- W3034936371 modified "2023-10-05" @default.
- W3034936371 title "The role of antibodies in Bacille Calmette Guérin-mediated immune responses and protection against tuberculosis in humans: A systematic review" @default.
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- W3034936371 doi "https://doi.org/10.1016/j.tube.2020.101947" @default.
- W3034936371 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33691988" @default.
- W3034936371 hasPublicationYear "2021" @default.
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