Matches in SemOpenAlex for { <https://semopenalex.org/work/W3034942040> ?p ?o ?g. }
- W3034942040 endingPage "840" @default.
- W3034942040 startingPage "829" @default.
- W3034942040 abstract "Introduction There is an increasing interest to individualize patient management and decisions regarding antibiotic treatment. Biomarkers may provide relevant information for this purpose.Areas covered Despite a growing number of clinical trials investigating several biomarkers, there remain open questions regarding the best type of biomarker, timing or frequency of testing, and optimal cutoffs among others. The most promising results in regard to diagnosis of bacterial infection and therapy monitoring are found for procalcitonin (PCT), although some recent trials were not able to validate the promising earlier findings. Furthermore, less specific markers like C-reactive protein (CRP) and new prognostic biomarkers such as proadrenomedullin (MR-proADM) may improve the prognostic assessment of patients and proteomics may help shorten time to microbiological results. The aim of this review is to summarize the current concept of biomarker-guided management and provide an outlook of promising ongoing investigations.Expert opinion ‘Antibiotic stewardship’ is complex and needs more than just the measurement of one single biomarker. However, when integrated into the context of a thorough clinical examination, standard blood parameters and a well done risk stratification by clinical scores such as the SOFA-score, biomarkers have great potential to improve the diagnostic and prognostic assessment of patients." @default.
- W3034942040 created "2020-06-19" @default.
- W3034942040 creator A5009399166 @default.
- W3034942040 creator A5022149453 @default.
- W3034942040 creator A5034814445 @default.
- W3034942040 creator A5037540908 @default.
- W3034942040 creator A5047065502 @default.
- W3034942040 date "2020-06-27" @default.
- W3034942040 modified "2023-10-01" @default.
- W3034942040 title "The value of biomarker-guided antibiotic therapy" @default.
- W3034942040 cites W135481481 @default.
- W3034942040 cites W1558281218 @default.
- W3034942040 cites W1662635338 @default.
- W3034942040 cites W1852407256 @default.
- W3034942040 cites W1894041801 @default.
- W3034942040 cites W1927433184 @default.
- W3034942040 cites W1946039161 @default.
- W3034942040 cites W1967120228 @default.
- W3034942040 cites W1969491266 @default.
- W3034942040 cites W1971792699 @default.
- W3034942040 cites W1973418837 @default.
- W3034942040 cites W1974061101 @default.
- W3034942040 cites W1974204067 @default.
- W3034942040 cites W1975117581 @default.
- W3034942040 cites W1975859872 @default.
- W3034942040 cites W1977434331 @default.
- W3034942040 cites W1983362446 @default.
- W3034942040 cites W1986442796 @default.
- W3034942040 cites W1987764661 @default.
- W3034942040 cites W1996115257 @default.
- W3034942040 cites W1999333369 @default.
- W3034942040 cites W2004689339 @default.
- W3034942040 cites W2008548231 @default.
- W3034942040 cites W2011462556 @default.
- W3034942040 cites W2015329932 @default.
- W3034942040 cites W2015464721 @default.
- W3034942040 cites W2018800031 @default.
- W3034942040 cites W2019274588 @default.
- W3034942040 cites W2023220528 @default.
- W3034942040 cites W2024333911 @default.
- W3034942040 cites W2028473226 @default.
- W3034942040 cites W2031870392 @default.
- W3034942040 cites W2032086632 @default.
- W3034942040 cites W2034781418 @default.
- W3034942040 cites W2036545847 @default.
- W3034942040 cites W2044729267 @default.
- W3034942040 cites W2052100013 @default.
- W3034942040 cites W2052330308 @default.
- W3034942040 cites W2053501504 @default.
- W3034942040 cites W2061512981 @default.
- W3034942040 cites W2061679651 @default.
- W3034942040 cites W2062356168 @default.
- W3034942040 cites W2070074382 @default.
- W3034942040 cites W2072886969 @default.
- W3034942040 cites W2073316020 @default.
- W3034942040 cites W2082293375 @default.
- W3034942040 cites W2084112246 @default.
- W3034942040 cites W2084438668 @default.
- W3034942040 cites W2085544415 @default.
- W3034942040 cites W2085565400 @default.
- W3034942040 cites W2088087647 @default.
- W3034942040 cites W2090140794 @default.
- W3034942040 cites W2092419989 @default.
- W3034942040 cites W2095989309 @default.
- W3034942040 cites W2096584623 @default.
- W3034942040 cites W2097582396 @default.
- W3034942040 cites W2097721935 @default.
- W3034942040 cites W2098691243 @default.
- W3034942040 cites W2101082552 @default.
- W3034942040 cites W2102563147 @default.
- W3034942040 cites W2104583114 @default.
- W3034942040 cites W2105249258 @default.
- W3034942040 cites W2107912229 @default.
- W3034942040 cites W2113324161 @default.
- W3034942040 cites W2115774683 @default.
- W3034942040 cites W2124191974 @default.
- W3034942040 cites W2125056753 @default.
- W3034942040 cites W2130611224 @default.
- W3034942040 cites W2131681584 @default.
- W3034942040 cites W2132436071 @default.
- W3034942040 cites W2132959667 @default.
- W3034942040 cites W2152354908 @default.
- W3034942040 cites W2155788368 @default.
- W3034942040 cites W2160691650 @default.
- W3034942040 cites W2160739269 @default.
- W3034942040 cites W2161838725 @default.
- W3034942040 cites W2163793198 @default.
- W3034942040 cites W2164849242 @default.
- W3034942040 cites W2165760729 @default.
- W3034942040 cites W2165960214 @default.
- W3034942040 cites W2280404143 @default.
- W3034942040 cites W2289242065 @default.
- W3034942040 cites W2320077053 @default.
- W3034942040 cites W2326303711 @default.
- W3034942040 cites W2334046462 @default.
- W3034942040 cites W2344273902 @default.
- W3034942040 cites W2425639548 @default.
- W3034942040 cites W2442246762 @default.