Matches in SemOpenAlex for { <https://semopenalex.org/work/W3034963477> ?p ?o ?g. }
- W3034963477 abstract "ABSTRACT Sequence overlap between two genes is common across all genomes, with viruses having high proportions of these gene overlaps. The biological function and fitness effects of gene overlaps are not fully understood, and their effects on gene cluster and genome-level refactoring are unknown. The bacteriophage ϕX174 genome has ∼26% of nucleotides involved in encoding more than one gene. In this study we use an engineered ϕX174 phage containing a genome with all gene overlaps removed, to show that gene overlap is critical to maintaining optimal viral fecundity. Through detailed phenotypic measurements we reveal that genome modularization in ϕX174 causes virion replication, stability, and attachment deficiencies. Quantitation of the complete phage proteome across an infection cycle reveals almost half the proteins display abnormal expression patterns. Taken together, we have for the first time comprehensively demonstrated that gene modularization severely perturbs the coordinated functioning of a bacteriophage replication cycle. This work highlights the biological importance of gene overlap in natural genomes and that reducing gene overlap disruption should be an integral part of future genome engineering projects." @default.
- W3034963477 created "2020-06-19" @default.
- W3034963477 creator A5007680869 @default.
- W3034963477 creator A5028575800 @default.
- W3034963477 creator A5069735960 @default.
- W3034963477 creator A5088291243 @default.
- W3034963477 date "2020-06-12" @default.
- W3034963477 modified "2023-10-18" @default.
- W3034963477 title "Genome modularization reveals overlapped gene topology is necessary for efficient viral reproduction" @default.
- W3034963477 cites W114564532 @default.
- W3034963477 cites W1501299499 @default.
- W3034963477 cites W1545713086 @default.
- W3034963477 cites W1595559221 @default.
- W3034963477 cites W1598176384 @default.
- W3034963477 cites W1614600542 @default.
- W3034963477 cites W1668539454 @default.
- W3034963477 cites W1733747220 @default.
- W3034963477 cites W1830948925 @default.
- W3034963477 cites W1939654294 @default.
- W3034963477 cites W1963252475 @default.
- W3034963477 cites W1967481935 @default.
- W3034963477 cites W1976257434 @default.
- W3034963477 cites W1978242314 @default.
- W3034963477 cites W1979076392 @default.
- W3034963477 cites W1979154939 @default.
- W3034963477 cites W1989020100 @default.
- W3034963477 cites W1989600727 @default.
- W3034963477 cites W1990397154 @default.
- W3034963477 cites W1995039292 @default.
- W3034963477 cites W2000588645 @default.
- W3034963477 cites W2006570795 @default.
- W3034963477 cites W2007370729 @default.
- W3034963477 cites W2007678580 @default.
- W3034963477 cites W2008108501 @default.
- W3034963477 cites W2009965783 @default.
- W3034963477 cites W2011665065 @default.
- W3034963477 cites W2021797720 @default.
- W3034963477 cites W2026027178 @default.
- W3034963477 cites W2028010103 @default.
- W3034963477 cites W2031596486 @default.
- W3034963477 cites W2032464841 @default.
- W3034963477 cites W2036663020 @default.
- W3034963477 cites W2038552200 @default.
- W3034963477 cites W2047224020 @default.
- W3034963477 cites W2051757632 @default.
- W3034963477 cites W2054225539 @default.
- W3034963477 cites W2059458164 @default.
- W3034963477 cites W2065758222 @default.
- W3034963477 cites W2066183174 @default.
- W3034963477 cites W2071157034 @default.
- W3034963477 cites W2071755759 @default.
- W3034963477 cites W2076708252 @default.
- W3034963477 cites W2076990756 @default.
- W3034963477 cites W2078352346 @default.
- W3034963477 cites W2080752012 @default.
- W3034963477 cites W2086561953 @default.
- W3034963477 cites W2092247774 @default.
- W3034963477 cites W2094016018 @default.
- W3034963477 cites W2094734971 @default.
- W3034963477 cites W2095226800 @default.
- W3034963477 cites W2095324053 @default.
- W3034963477 cites W2096916417 @default.
- W3034963477 cites W2103808129 @default.
- W3034963477 cites W2104065958 @default.
- W3034963477 cites W2104234755 @default.
- W3034963477 cites W2104921450 @default.
- W3034963477 cites W2105167594 @default.
- W3034963477 cites W2107424557 @default.
- W3034963477 cites W2108672804 @default.
- W3034963477 cites W2111548417 @default.
- W3034963477 cites W2111967267 @default.
- W3034963477 cites W2112269135 @default.
- W3034963477 cites W2113038412 @default.
- W3034963477 cites W2114856602 @default.
- W3034963477 cites W2115486909 @default.
- W3034963477 cites W2118250336 @default.
- W3034963477 cites W2119716854 @default.
- W3034963477 cites W2120380796 @default.
- W3034963477 cites W2121529254 @default.
- W3034963477 cites W2122686110 @default.
- W3034963477 cites W2125836280 @default.
- W3034963477 cites W2127501111 @default.
- W3034963477 cites W2128588803 @default.
- W3034963477 cites W2131041596 @default.
- W3034963477 cites W2132784913 @default.
- W3034963477 cites W2133405018 @default.
- W3034963477 cites W2139566973 @default.
- W3034963477 cites W2141091417 @default.
- W3034963477 cites W2141157874 @default.
- W3034963477 cites W2141776974 @default.
- W3034963477 cites W2146141532 @default.
- W3034963477 cites W2147043714 @default.
- W3034963477 cites W2149174733 @default.
- W3034963477 cites W2154529222 @default.
- W3034963477 cites W2154589788 @default.
- W3034963477 cites W2158444209 @default.
- W3034963477 cites W2161153002 @default.
- W3034963477 cites W2161493476 @default.
- W3034963477 cites W2165472199 @default.
- W3034963477 cites W2171445530 @default.