FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3034971276> ?p ?o ?g. }

• W3034971276 endingPage "543" @default.
• W3034971276 startingPage "536" @default.
• W3034971276 abstract "BACKGROUND We have shown that administration of mesenchymal stem cell–derived exosomes (single dose given within 1 hour) in models of traumatic brain injury (TBI) and hemorrhagic shock is neuroprotective. The precise mechanisms responsible for the neuroprotection are not fully understood. This study was designed to investigate the transcriptomic changes in the brain that are associated with this treatment strategy. METHODS Yorkshire swine (40–45 kg) were subjected to a severe TBI (12-mm cortical impact) and hemorrhagic shock (40% estimated total blood volume). One hour into shock, animals were randomized (n = 5/cohort) to receive either lactated Ringer's (LR; 5 mL) or exosomes suspended in LR (LR + EXO; 1 × 10 13 exosome particles in 5 mL LR). Animals then underwent additional shock (1 hour) followed by normal saline resuscitation. After 6 hours of observation, brain swelling (% increase compared with the uninjured side) and lesion size (mm 3 ) were assessed. Periinjured brain tissue was processed for RNA sequencing, analyzed with high through-put RNA sequencing data analysis, and results compared between control and experimental groups. RESULTS Exosome treatment significantly increased ( p < 0.005) gene expression associated with neurogenesis, neuronal development, synaptogenesis, and neuroplasticity. It also significantly reduced ( p < 0.005) genes associated with stroke, neuroinflammation, neuroepithelial cell proliferation, and nonneuronal cell proliferation contributing to reactive gliosis. Exosome treatment also significantly increased ( p < 0.005) the genes that are associated with stability of blood-brain barrier. CONCLUSIONS Administration of a single dose of exosomes induces transcriptomic changes suggestive of neuroprotection. Their use as a treatment for TBI is promising and requires further investigation for human translation." @default.
• W3034971276 created "2020-06-19" @default.
• W3034971276 creator A5006735523 @default.
• W3034971276 creator A5013695013 @default.
• W3034971276 creator A5022058940 @default.
• W3034971276 creator A5032642797 @default.
• W3034971276 creator A5037745908 @default.
• W3034971276 creator A5047595060 @default.
• W3034971276 creator A5054859377 @default.
• W3034971276 creator A5056658843 @default.
• W3034971276 creator A5058961918 @default.
• W3034971276 creator A5062993507 @default.
• W3034971276 creator A5072830760 @default.
• W3034971276 creator A5075188273 @default.
• W3034971276 creator A5078318043 @default.
• W3034971276 creator A5084194555 @default.
• W3034971276 date "2020-09-01" @default.
• W3034971276 modified "2023-10-03" @default.
• W3034971276 title "Early treatment with exosomes following traumatic brain injury and hemorrhagic shock in a swine model promotes transcriptional changes associated with neuroprotection" @default.
• W3034971276 cites W1965490997 @default.
• W3034971276 cites W1997435185 @default.
• W3034971276 cites W2000422049 @default.
• W3034971276 cites W2036913140 @default.
• W3034971276 cites W2050889407 @default.
• W3034971276 cites W2056143628 @default.
• W3034971276 cites W2067451082 @default.
• W3034971276 cites W2068344204 @default.
• W3034971276 cites W2068352803 @default.
• W3034971276 cites W2072666769 @default.
• W3034971276 cites W2077927847 @default.
• W3034971276 cites W2081191481 @default.
• W3034971276 cites W2084962044 @default.
• W3034971276 cites W2162143298 @default.
• W3034971276 cites W2168120562 @default.
• W3034971276 cites W2411684004 @default.
• W3034971276 cites W2513598842 @default.
• W3034971276 cites W2560127228 @default.
• W3034971276 cites W2595085771 @default.
• W3034971276 cites W2744245692 @default.
• W3034971276 cites W2766564437 @default.
• W3034971276 cites W2771992923 @default.
• W3034971276 cites W2773781615 @default.
• W3034971276 cites W2786514708 @default.
• W3034971276 cites W2801941054 @default.
• W3034971276 cites W2807011124 @default.
• W3034971276 cites W2809398132 @default.
• W3034971276 cites W2812247244 @default.
• W3034971276 cites W2897805491 @default.
• W3034971276 cites W2900044275 @default.
• W3034971276 cites W2905428026 @default.
• W3034971276 cites W2913225062 @default.
• W3034971276 cites W2914833536 @default.
• W3034971276 cites W2922260431 @default.
• W3034971276 cites W2936948584 @default.
• W3034971276 cites W2949254839 @default.
• W3034971276 cites W2950985970 @default.
• W3034971276 cites W2972804872 @default.
• W3034971276 cites W2990551073 @default.
• W3034971276 cites W2992824064 @default.
• W3034971276 cites W3011825821 @default.
• W3034971276 cites W4297069145 @default.
• W3034971276 doi "https://doi.org/10.1097/ta.0000000000002815" @default.
• W3034971276 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32658440" @default.
• W3034971276 hasPublicationYear "2020" @default.
• W3034971276 type Work @default.
• W3034971276 sameAs 3034971276 @default.
• W3034971276 citedByCount "16" @default.
• W3034971276 countsByYear W30349712762021 @default.
• W3034971276 countsByYear W30349712762022 @default.
• W3034971276 countsByYear W30349712762023 @default.
• W3034971276 crossrefType "journal-article" @default.
• W3034971276 hasAuthorship W3034971276A5006735523 @default.
• W3034971276 hasAuthorship W3034971276A5013695013 @default.
• W3034971276 hasAuthorship W3034971276A5022058940 @default.
• W3034971276 hasAuthorship W3034971276A5032642797 @default.
• W3034971276 hasAuthorship W3034971276A5037745908 @default.
• W3034971276 hasAuthorship W3034971276A5047595060 @default.
• W3034971276 hasAuthorship W3034971276A5054859377 @default.
• W3034971276 hasAuthorship W3034971276A5056658843 @default.
• W3034971276 hasAuthorship W3034971276A5058961918 @default.
• W3034971276 hasAuthorship W3034971276A5062993507 @default.
• W3034971276 hasAuthorship W3034971276A5072830760 @default.
• W3034971276 hasAuthorship W3034971276A5075188273 @default.
• W3034971276 hasAuthorship W3034971276A5078318043 @default.
• W3034971276 hasAuthorship W3034971276A5084194555 @default.
• W3034971276 hasConcept C104317684 @default.
• W3034971276 hasConcept C118552586 @default.
• W3034971276 hasConcept C126322002 @default.
• W3034971276 hasConcept C142724271 @default.
• W3034971276 hasConcept C145059251 @default.
• W3034971276 hasConcept C20518536 @default.
• W3034971276 hasConcept C25498285 @default.
• W3034971276 hasConcept C2776914184 @default.
• W3034971276 hasConcept C2777682930 @default.
• W3034971276 hasConcept C2781017439 @default.
• W3034971276 hasConcept C2781261824 @default.
• W3034971276 hasConcept C2781458332 @default.
• W3034971276 hasConcept C42219234 @default.

• next