FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3034971323> ?p ?o ?g. }

• W3034971323 endingPage "964" @default.
• W3034971323 startingPage "943" @default.
• W3034971323 abstract "Abstract Background Although humans are exposed to mixtures of endocrine disruptor chemicals, few studies have examined their toxicity on male reproduction. We previously found that fetal exposure to a mixture of the phytoestrogen genistein (GEN) and the plasticizer di(2‐ethylhexyl) phthalate (DEHP) altered gene expression in adult rat testes. Objectives Our goal was to investigate the effects of fetal exposure to GEN‐DEHP mixtures at two doses relevant to humans on testicular function and transcriptome in neonatal and adult rats. Materials and methods Pregnant SD rats were gavaged with vehicle, GEN or DEHP, alone or mixed at 0.1 and 10 mg/kg/day, from gestation day 14 to birth. Fertility, steroid levels, and testis morphology were examined in neonatal and adult rats. Testicular transcriptomes were examined by gene array and functional pathway analyses. Cell‐specific genes/proteins were determined by quantitative real‐time PCR and immunohistochemistry. Results GEN‐DEHP mixtures increased the rates of infertility and abnormal testes in adult rats. Gene array analysis identified more genes exclusively altered by the mixtures than individual compounds. Altered top canonical pathways included urogenital/reproductive developmental and inflammatory processes. GEN‐DEHP mixtures increased innate immune cells and macrophages markers at both doses and ages, more strongly and consistently than DEHP or GEN alone. Genes exclusively increased by the mixture in adult testis related to innate immune cells and macrophages included Kitlg, Rps6ka3 (Rsk2) , Nr3c1 , Nqo1 , Lif , Fyn , Ptprj ( Dep‐1 ), Gpr116 , Pfn2, and Ptgr1 . Discussion and conclusion These findings demonstrate that GEN‐DEHP mixtures at doses relevant to human induce adverse testicular phenotypes, concurrent with age‐dependent and non‐monotonic changes in testicular transcriptomes. The involvement of innate immune cells such as macrophages suggests immediate and delayed inflammatory responses which may contribute to testicular dysfunction. Moreover, these effects are complex and likely involve multiple interactions between immune and non‐immune testicular cell types that will entail further studies." @default.
• W3034971323 created "2020-06-19" @default.
• W3034971323 creator A5023640728 @default.
• W3034971323 creator A5048076614 @default.
• W3034971323 creator A5085530159 @default.
• W3034971323 creator A5085702940 @default.
• W3034971323 creator A5091319488 @default.
• W3034971323 date "2020-07-01" @default.
• W3034971323 modified "2023-10-09" @default.
• W3034971323 title "In utero exposure to low doses of genistein and di‐(2‐ethylhexyl) phthalate (DEHP) alters innate immune cells in neonatal and adult rat testes" @default.
• W3034971323 cites W1967832563 @default.
• W3034971323 cites W1968074438 @default.
• W3034971323 cites W1973660349 @default.
• W3034971323 cites W1974082627 @default.
• W3034971323 cites W1975922780 @default.
• W3034971323 cites W1978122943 @default.
• W3034971323 cites W1981264454 @default.
• W3034971323 cites W1982241280 @default.
• W3034971323 cites W1983290283 @default.
• W3034971323 cites W1985374659 @default.
• W3034971323 cites W1986071278 @default.
• W3034971323 cites W1991757963 @default.
• W3034971323 cites W1993246250 @default.
• W3034971323 cites W1994300634 @default.
• W3034971323 cites W1996131998 @default.
• W3034971323 cites W1996962673 @default.
• W3034971323 cites W2010959713 @default.
• W3034971323 cites W2015275965 @default.
• W3034971323 cites W2015527748 @default.
• W3034971323 cites W2016509061 @default.
• W3034971323 cites W2025373842 @default.
• W3034971323 cites W2028728873 @default.
• W3034971323 cites W2030671980 @default.
• W3034971323 cites W2030724582 @default.
• W3034971323 cites W2035474512 @default.
• W3034971323 cites W2035981981 @default.
• W3034971323 cites W2041846642 @default.
• W3034971323 cites W2057320534 @default.
• W3034971323 cites W2059166339 @default.
• W3034971323 cites W2065539371 @default.
• W3034971323 cites W2071018426 @default.
• W3034971323 cites W2071117491 @default.
• W3034971323 cites W2071165514 @default.
• W3034971323 cites W2073718466 @default.
• W3034971323 cites W2074938706 @default.
• W3034971323 cites W2076978846 @default.
• W3034971323 cites W2088008535 @default.
• W3034971323 cites W2096414999 @default.
• W3034971323 cites W2097049516 @default.
• W3034971323 cites W2097327668 @default.
• W3034971323 cites W2097568021 @default.
• W3034971323 cites W2102421434 @default.
• W3034971323 cites W2106712145 @default.
• W3034971323 cites W2106746131 @default.
• W3034971323 cites W2109516127 @default.
• W3034971323 cites W2109971484 @default.
• W3034971323 cites W2110463517 @default.
• W3034971323 cites W2111854468 @default.
• W3034971323 cites W2118015545 @default.
• W3034971323 cites W2119832874 @default.
• W3034971323 cites W2120106657 @default.
• W3034971323 cites W2122488988 @default.
• W3034971323 cites W2123272922 @default.
• W3034971323 cites W2124722798 @default.
• W3034971323 cites W2128664610 @default.
• W3034971323 cites W2130172024 @default.
• W3034971323 cites W2130594874 @default.
• W3034971323 cites W2137585111 @default.
• W3034971323 cites W2139002248 @default.
• W3034971323 cites W2145332532 @default.
• W3034971323 cites W2148619299 @default.
• W3034971323 cites W2150205603 @default.
• W3034971323 cites W2150860038 @default.
• W3034971323 cites W2152599023 @default.
• W3034971323 cites W2153725665 @default.
• W3034971323 cites W2154715879 @default.
• W3034971323 cites W2157936339 @default.
• W3034971323 cites W2171954029 @default.
• W3034971323 cites W2178071610 @default.
• W3034971323 cites W2190800365 @default.
• W3034971323 cites W2265952622 @default.
• W3034971323 cites W2360358288 @default.
• W3034971323 cites W2412463294 @default.
• W3034971323 cites W2480324400 @default.
• W3034971323 cites W2503753278 @default.
• W3034971323 cites W2529730976 @default.
• W3034971323 cites W2537873672 @default.
• W3034971323 cites W2555165693 @default.
• W3034971323 cites W2736387752 @default.
• W3034971323 cites W2769433822 @default.
• W3034971323 cites W2782685575 @default.
• W3034971323 cites W2796213339 @default.
• W3034971323 cites W2810795907 @default.
• W3034971323 cites W2906229866 @default.
• W3034971323 cites W2951675934 @default.
• W3034971323 cites W2982635577 @default.
• W3034971323 cites W2985021498 @default.
• W3034971323 cites W2994154464 @default.

• next