FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3035003082> ?p ?o ?g. }

• W3035003082 abstract "Introduction: High dose methotrexate (HD-Mtx) is highly effective and significantly improve overall acute lymphoblastic leukemia (ALL) patients survival. The pharmacodynamics of Mtx depends on the polymorphism of genes encoding proteins engaged in the folate metabolism pathway. The aim of the current study is to determine the relationship between variants of folate metabolism-related genes and the frequency of acute toxicities of HD-Mtx. Material and Methods: A group of 133 patients aged 1.5 to 18.1 years (median: 6.3) was treated in accordance with the ALL-IC-2002 and ALL-IC-2009 protocols. The following polymorphisms were determined: 80 G>A SLC19A1 (solute carrier family 19 member 1; rs1051266) with direct DNA sequencing, as well as 677 C>T MTHFR (methylenetetrahydrofolate reductase; rs1801133) and the tandem repeats of the TS (thymidylate synthase) with PCR technique. HD-Mtx organ toxicities were evaluated based on the laboratory tests results and the National Cancer Institute criteria. Results: In patients with genotypes AA for SLC19A1 and CC or CT for MTHFR Mtx steady state concentrations (Css) and AUCinf were distinctly higher. In patients with genotype 3R/3R for TS initial elimination rate constant was significantly higher (P=0.003). Patients receiving Mtx at the dose of 5 g/m2 had lower clearance (4.35 vs 8.92 L/h/m2) as compared to the ones receiving 2 g/m2 that indicates nonlinear Mtx elimination at the higher dose. Liver impairment was the most frequently observed toxicity. The homozygous genotype was associated with a significantly higher incidence of hepatic toxicity for both the SLC19A1 (P=0.037) and TS (P=0.002). Logistic regression analysis indicated an increased risk of vomiting for the 2R/3R genotype of the TS gene (OR 3.20, 95% CI 1.33-7.68, P=0.009) and for vomiting and hepatic toxicity for the 3R/3R genotype (vomiting: OR 3.39, 95% CI 1.12-10.23, P=0.031; liver toxicity: OR 2.28, 95% CI 1.05-4.95, P=0.038). None of the acute toxicities differed between the analyzed dosing groups. Conclusions: Determination of polymorphisms of SLC19A1, MTHFR and TS genes might allow for a better prior selection of patients with higher risk of elevated Mtx levels. Our study is the first one to report the increased risk of hepatotoxicity and vomiting in patients with TS polymorphisms." @default.
• W3035003082 created "2020-06-19" @default.
• W3035003082 creator A5007855211 @default.
• W3035003082 creator A5026173649 @default.
• W3035003082 creator A5028015453 @default.
• W3035003082 creator A5034406880 @default.
• W3035003082 creator A5035835858 @default.
• W3035003082 creator A5036855099 @default.
• W3035003082 creator A5040158837 @default.
• W3035003082 creator A5055296585 @default.
• W3035003082 creator A5059423213 @default.
• W3035003082 creator A5061768808 @default.
• W3035003082 creator A5061936516 @default.
• W3035003082 creator A5063002438 @default.
• W3035003082 creator A5067782930 @default.
• W3035003082 creator A5068181128 @default.
• W3035003082 creator A5068711438 @default.
• W3035003082 creator A5071491448 @default.
• W3035003082 date "2020-06-16" @default.
• W3035003082 modified "2023-10-18" @default.
• W3035003082 title "Polymorphisms of SLC19A1 80 G>A, MTHFR 677 C>T, and Tandem TS Repeats Influence Pharmacokinetics, Acute Liver Toxicity, and Vomiting in Children With Acute Lymphoblastic Leukemia Treated With High Doses of Methotrexate" @default.
• W3035003082 cites W1963799733 @default.
• W3035003082 cites W1968553828 @default.
• W3035003082 cites W1971336136 @default.
• W3035003082 cites W1974895424 @default.
• W3035003082 cites W1983160858 @default.
• W3035003082 cites W1989040946 @default.
• W3035003082 cites W1991884361 @default.
• W3035003082 cites W1999245101 @default.
• W3035003082 cites W2004640207 @default.
• W3035003082 cites W2013138837 @default.
• W3035003082 cites W2016058563 @default.
• W3035003082 cites W2022162825 @default.
• W3035003082 cites W2026445506 @default.
• W3035003082 cites W2037966160 @default.
• W3035003082 cites W2041473512 @default.
• W3035003082 cites W2050229607 @default.
• W3035003082 cites W2051846486 @default.
• W3035003082 cites W2062738339 @default.
• W3035003082 cites W2063703838 @default.
• W3035003082 cites W2063725536 @default.
• W3035003082 cites W2066651895 @default.
• W3035003082 cites W2071035298 @default.
• W3035003082 cites W2071818770 @default.
• W3035003082 cites W2072667440 @default.
• W3035003082 cites W2077718321 @default.
• W3035003082 cites W2083654601 @default.
• W3035003082 cites W2083944628 @default.
• W3035003082 cites W2086992699 @default.
• W3035003082 cites W2091018813 @default.
• W3035003082 cites W2120071742 @default.
• W3035003082 cites W2128800587 @default.
• W3035003082 cites W2129228847 @default.
• W3035003082 cites W2135630212 @default.
• W3035003082 cites W2141998397 @default.
• W3035003082 cites W2143747153 @default.
• W3035003082 cites W2143755247 @default.
• W3035003082 cites W2145619276 @default.
• W3035003082 cites W2145688542 @default.
• W3035003082 cites W2145956223 @default.
• W3035003082 cites W2290546543 @default.
• W3035003082 cites W2322263796 @default.
• W3035003082 cites W2605654758 @default.
• W3035003082 cites W2791883062 @default.
• W3035003082 cites W2883142851 @default.
• W3035003082 cites W2925170766 @default.
• W3035003082 cites W2993940740 @default.
• W3035003082 cites W3000274414 @default.
• W3035003082 cites W383623464 @default.
• W3035003082 doi "https://doi.org/10.3389/fped.2020.00307" @default.
• W3035003082 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7308427" @default.
• W3035003082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32612964" @default.
• W3035003082 hasPublicationYear "2020" @default.
• W3035003082 type Work @default.
• W3035003082 sameAs 3035003082 @default.
• W3035003082 citedByCount "10" @default.
• W3035003082 countsByYear W30350030822021 @default.
• W3035003082 countsByYear W30350030822022 @default.
• W3035003082 countsByYear W30350030822023 @default.
• W3035003082 crossrefType "journal-article" @default.
• W3035003082 hasAuthorship W3035003082A5007855211 @default.
• W3035003082 hasAuthorship W3035003082A5026173649 @default.
• W3035003082 hasAuthorship W3035003082A5028015453 @default.
• W3035003082 hasAuthorship W3035003082A5034406880 @default.
• W3035003082 hasAuthorship W3035003082A5035835858 @default.
• W3035003082 hasAuthorship W3035003082A5036855099 @default.
• W3035003082 hasAuthorship W3035003082A5040158837 @default.
• W3035003082 hasAuthorship W3035003082A5055296585 @default.
• W3035003082 hasAuthorship W3035003082A5059423213 @default.
• W3035003082 hasAuthorship W3035003082A5061768808 @default.
• W3035003082 hasAuthorship W3035003082A5061936516 @default.
• W3035003082 hasAuthorship W3035003082A5063002438 @default.
• W3035003082 hasAuthorship W3035003082A5067782930 @default.
• W3035003082 hasAuthorship W3035003082A5068181128 @default.
• W3035003082 hasAuthorship W3035003082A5068711438 @default.
• W3035003082 hasAuthorship W3035003082A5071491448 @default.
• W3035003082 hasBestOaLocation W30350030821 @default.
• W3035003082 hasConcept C104317684 @default.
• W3035003082 hasConcept C111113717 @default.
• W3035003082 hasConcept C112705442 @default.

• next