Matches in SemOpenAlex for { <https://semopenalex.org/work/W3035004775> ?p ?o ?g. }
- W3035004775 endingPage "257.e6" @default.
- W3035004775 startingPage "245" @default.
- W3035004775 abstract "The human microbiome encodes extensive metabolic capabilities, but our understanding of the mechanisms linking gut microbes to human metabolism remains limited. Here, we focus on the conversion of cholesterol to the poorly absorbed sterol coprostanol by the gut microbiota to develop a framework for the identification of functional enzymes and microbes. By integrating paired metagenomics and metabolomics data from existing cohorts with biochemical knowledge and experimentation, we predict and validate a group of microbial cholesterol dehydrogenases that contribute to coprostanol formation. These enzymes are encoded by ismA genes in a clade of uncultured microorganisms, which are prevalent in geographically diverse human cohorts. Individuals harboring coprostanol-forming microbes have significantly lower fecal cholesterol levels and lower serum total cholesterol with effects comparable to those attributed to variations in lipid homeostasis genes. Thus, cholesterol metabolism by these microbes may play important roles in reducing intestinal and serum cholesterol concentrations, directly impacting human health." @default.
- W3035004775 created "2020-06-19" @default.
- W3035004775 creator A5001913769 @default.
- W3035004775 creator A5006524653 @default.
- W3035004775 creator A5034165585 @default.
- W3035004775 creator A5038468250 @default.
- W3035004775 creator A5050985673 @default.
- W3035004775 creator A5051681423 @default.
- W3035004775 creator A5056408708 @default.
- W3035004775 creator A5057268638 @default.
- W3035004775 creator A5065162279 @default.
- W3035004775 creator A5065574984 @default.
- W3035004775 creator A5071740181 @default.
- W3035004775 date "2020-08-01" @default.
- W3035004775 modified "2023-10-17" @default.
- W3035004775 title "Cholesterol Metabolism by Uncultured Human Gut Bacteria Influences Host Cholesterol Level" @default.
- W3035004775 cites W1521031298 @default.
- W3035004775 cites W1588582046 @default.
- W3035004775 cites W1703384511 @default.
- W3035004775 cites W1912959803 @default.
- W3035004775 cites W1918132278 @default.
- W3035004775 cites W1966594516 @default.
- W3035004775 cites W1979494873 @default.
- W3035004775 cites W1980157771 @default.
- W3035004775 cites W1980873478 @default.
- W3035004775 cites W1985003577 @default.
- W3035004775 cites W2001561488 @default.
- W3035004775 cites W2005292739 @default.
- W3035004775 cites W2008056925 @default.
- W3035004775 cites W2011222133 @default.
- W3035004775 cites W2020915011 @default.
- W3035004775 cites W2031611770 @default.
- W3035004775 cites W2039433435 @default.
- W3035004775 cites W2051235818 @default.
- W3035004775 cites W2053197082 @default.
- W3035004775 cites W2059032482 @default.
- W3035004775 cites W2060287557 @default.
- W3035004775 cites W2062852482 @default.
- W3035004775 cites W2071380138 @default.
- W3035004775 cites W2087577664 @default.
- W3035004775 cites W2097124003 @default.
- W3035004775 cites W2102461176 @default.
- W3035004775 cites W2103441770 @default.
- W3035004775 cites W2110171695 @default.
- W3035004775 cites W2112364185 @default.
- W3035004775 cites W2112738213 @default.
- W3035004775 cites W2113679889 @default.
- W3035004775 cites W2116346071 @default.
- W3035004775 cites W2116404316 @default.
- W3035004775 cites W2116913446 @default.
- W3035004775 cites W2120902911 @default.
- W3035004775 cites W2123341306 @default.
- W3035004775 cites W2124351063 @default.
- W3035004775 cites W2125826054 @default.
- W3035004775 cites W2126930838 @default.
- W3035004775 cites W2131271579 @default.
- W3035004775 cites W2134149420 @default.
- W3035004775 cites W2143485490 @default.
- W3035004775 cites W2153118028 @default.
- W3035004775 cites W2160347316 @default.
- W3035004775 cites W2166123725 @default.
- W3035004775 cites W2170747616 @default.
- W3035004775 cites W2223752691 @default.
- W3035004775 cites W2548957578 @default.
- W3035004775 cites W2586155766 @default.
- W3035004775 cites W2604323123 @default.
- W3035004775 cites W2625565554 @default.
- W3035004775 cites W2716699759 @default.
- W3035004775 cites W2745006471 @default.
- W3035004775 cites W2749743535 @default.
- W3035004775 cites W2761865284 @default.
- W3035004775 cites W2787902098 @default.
- W3035004775 cites W2803957581 @default.
- W3035004775 cites W2884910880 @default.
- W3035004775 cites W2900629010 @default.
- W3035004775 cites W2903267537 @default.
- W3035004775 cites W2903406988 @default.
- W3035004775 cites W2904950674 @default.
- W3035004775 cites W2910587862 @default.
- W3035004775 cites W2910615673 @default.
- W3035004775 cites W2911391319 @default.
- W3035004775 cites W2912883243 @default.
- W3035004775 cites W2912990896 @default.
- W3035004775 cites W2913972921 @default.
- W3035004775 cites W2920716817 @default.
- W3035004775 cites W2938364298 @default.
- W3035004775 cites W2947189704 @default.
- W3035004775 cites W2951254987 @default.
- W3035004775 cites W2951517287 @default.
- W3035004775 cites W2990140906 @default.
- W3035004775 cites W2997490540 @default.
- W3035004775 cites W3007555042 @default.
- W3035004775 cites W4250616307 @default.
- W3035004775 cites W958079127 @default.
- W3035004775 doi "https://doi.org/10.1016/j.chom.2020.05.013" @default.
- W3035004775 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7435688" @default.
- W3035004775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32544460" @default.
- W3035004775 hasPublicationYear "2020" @default.