FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3035012377> ?p ?o ?g. }

• W3035012377 endingPage "109182" @default.
• W3035012377 startingPage "109182" @default.
• W3035012377 abstract "Nothofagin is a natural 3′-C-β-D-glucoside of the polyphenol phloretin that is mainly found in Aspalathus linearis, Nothofagus fusca, and Leandra dasytricha. In recent years, nothofagin has been described as a potential therapeutic agent for renal disorders, but the mechanisms that are involved in its renoprotective effects remain unclear. In the present study, perfused rat kidneys were used to test the hypothesis that nothofagin causes the direct relaxation of renal arteries. The molecular mechanisms that underlie these vascular effects were also investigated. The left kidney from Wistar rats was coupled in a perfusion system and continuously perfused with physiological saline solution (PSS). Initially, preparations with and without the endothelium were contracted with phenylephrine and received injections of 1–300 nmol nothofagin. The preparations were then perfused with PSS that contained phenylephrine plus KCl, indomethacin, l-NAME, tetraethylammonium, glibenclamide, 4-aminopyridine, iberiotoxin, charybdotoxin, and apamin. After 15 min under perfusion, nothofagin was injected again. In preparations with an intact endothelium, nothofagin dose-dependently reduced perfusion pressure. Endothelium removal or the inhibition of nitric oxide synthase by l-NAME prevented the vasodilatory effect of nothofagin at all doses tested. Perfusion with PSS that contained KCl or tetraethylammonium chloride also abolished the vasodilatory effect of nothofagin. Treatment with glibenclamide, 4-aminopyridine, and apamin did not affect the vasodilatory effect of nothofagin. Iberiotoxin (selective Ca2+-activated high-conductance K+ channel [KCa1.1] blocker) and charybdotoxin (selective KCa1.1 and Ca2+-activated intermediate-conductance K+ channel [KCa3.1] blocker) application blocked the vasodilatory effect of nothofagin at all doses tested, pointing to a predominant role for KCa1.1 in the action of nothofagin. However, these data cannot exclude a potential contribution of endothelial KCa3.1 channel in the nothofagin-induced vasodilation. Overall, our findings indicate that nothofagin induces vasodilation in renal arteries, an effect that is mediated by Ca2+ -activated high-conductance K+ channels opening and endothelial nitric oxide production." @default.
• W3035012377 created "2020-06-19" @default.
• W3035012377 creator A5003101642 @default.
• W3035012377 creator A5039235702 @default.
• W3035012377 creator A5040014037 @default.
• W3035012377 creator A5065648886 @default.
• W3035012377 creator A5070045140 @default.
• W3035012377 creator A5078046541 @default.
• W3035012377 creator A5085297367 @default.
• W3035012377 date "2020-08-01" @default.
• W3035012377 modified "2023-10-14" @default.
• W3035012377 title "Nitric oxide and Ca2+-activated high-conductance K+ channels mediate nothofagin-induced endothelium-dependent vasodilation in the perfused rat kidney" @default.
• W3035012377 cites W1774461274 @default.
• W3035012377 cites W1821918060 @default.
• W3035012377 cites W1944730036 @default.
• W3035012377 cites W1970136135 @default.
• W3035012377 cites W1971169490 @default.
• W3035012377 cites W1985236418 @default.
• W3035012377 cites W2001906061 @default.
• W3035012377 cites W2005038088 @default.
• W3035012377 cites W2050332830 @default.
• W3035012377 cites W2054418710 @default.
• W3035012377 cites W2054818418 @default.
• W3035012377 cites W2063503589 @default.
• W3035012377 cites W2065485342 @default.
• W3035012377 cites W2075447600 @default.
• W3035012377 cites W2089001660 @default.
• W3035012377 cites W2326417371 @default.
• W3035012377 cites W2593245077 @default.
• W3035012377 cites W2769433477 @default.
• W3035012377 cites W2774947008 @default.
• W3035012377 cites W2883559890 @default.
• W3035012377 cites W2898503436 @default.
• W3035012377 doi "https://doi.org/10.1016/j.cbi.2020.109182" @default.
• W3035012377 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32554038" @default.
• W3035012377 hasPublicationYear "2020" @default.
• W3035012377 type Work @default.
• W3035012377 sameAs 3035012377 @default.
• W3035012377 citedByCount "14" @default.
• W3035012377 countsByYear W30350123772020 @default.
• W3035012377 countsByYear W30350123772021 @default.
• W3035012377 countsByYear W30350123772022 @default.
• W3035012377 countsByYear W30350123772023 @default.
• W3035012377 crossrefType "journal-article" @default.
• W3035012377 hasAuthorship W3035012377A5003101642 @default.
• W3035012377 hasAuthorship W3035012377A5039235702 @default.
• W3035012377 hasAuthorship W3035012377A5040014037 @default.
• W3035012377 hasAuthorship W3035012377A5065648886 @default.
• W3035012377 hasAuthorship W3035012377A5070045140 @default.
• W3035012377 hasAuthorship W3035012377A5078046541 @default.
• W3035012377 hasAuthorship W3035012377A5085297367 @default.
• W3035012377 hasConcept C120770815 @default.
• W3035012377 hasConcept C126322002 @default.
• W3035012377 hasConcept C134018914 @default.
• W3035012377 hasConcept C153461711 @default.
• W3035012377 hasConcept C178790620 @default.
• W3035012377 hasConcept C185592680 @default.
• W3035012377 hasConcept C2776919887 @default.
• W3035012377 hasConcept C2776992346 @default.
• W3035012377 hasConcept C2777952589 @default.
• W3035012377 hasConcept C2779411790 @default.
• W3035012377 hasConcept C2779768347 @default.
• W3035012377 hasConcept C2780419564 @default.
• W3035012377 hasConcept C2780918503 @default.
• W3035012377 hasConcept C2781295685 @default.
• W3035012377 hasConcept C42219234 @default.
• W3035012377 hasConcept C517785266 @default.
• W3035012377 hasConcept C519063684 @default.
• W3035012377 hasConcept C519581460 @default.
• W3035012377 hasConcept C555293320 @default.
• W3035012377 hasConcept C71924100 @default.
• W3035012377 hasConcept C83743174 @default.
• W3035012377 hasConcept C84393581 @default.
• W3035012377 hasConcept C98274493 @default.
• W3035012377 hasConceptScore W3035012377C120770815 @default.
• W3035012377 hasConceptScore W3035012377C126322002 @default.
• W3035012377 hasConceptScore W3035012377C134018914 @default.
• W3035012377 hasConceptScore W3035012377C153461711 @default.
• W3035012377 hasConceptScore W3035012377C178790620 @default.
• W3035012377 hasConceptScore W3035012377C185592680 @default.
• W3035012377 hasConceptScore W3035012377C2776919887 @default.
• W3035012377 hasConceptScore W3035012377C2776992346 @default.
• W3035012377 hasConceptScore W3035012377C2777952589 @default.
• W3035012377 hasConceptScore W3035012377C2779411790 @default.
• W3035012377 hasConceptScore W3035012377C2779768347 @default.
• W3035012377 hasConceptScore W3035012377C2780419564 @default.
• W3035012377 hasConceptScore W3035012377C2780918503 @default.
• W3035012377 hasConceptScore W3035012377C2781295685 @default.
• W3035012377 hasConceptScore W3035012377C42219234 @default.
• W3035012377 hasConceptScore W3035012377C517785266 @default.
• W3035012377 hasConceptScore W3035012377C519063684 @default.
• W3035012377 hasConceptScore W3035012377C519581460 @default.
• W3035012377 hasConceptScore W3035012377C555293320 @default.
• W3035012377 hasConceptScore W3035012377C71924100 @default.
• W3035012377 hasConceptScore W3035012377C83743174 @default.
• W3035012377 hasConceptScore W3035012377C84393581 @default.
• W3035012377 hasConceptScore W3035012377C98274493 @default.
• W3035012377 hasFunder F4320322025 @default.

• next