FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3035030051> ?p ?o ?g. }

• W3035030051 endingPage "1671" @default.
• W3035030051 startingPage "1664" @default.
• W3035030051 abstract "Insomnia is a well-established risk factor for late-life depression, yet the intermediary mechanisms are not known. One plausible mechanism is dysregulation of the reward system, a common feature of depression. The main objective of the current study was to determine whether late-life insomnia is associated with reduced motivation and reduced sensitivity for monetary reward. Secondary exploratory objectives were to test for sex-specific effects and whether elevated inflammation potentiated these associations. Nondepressed community dwelling older adults (n = 104; aged 60-80) who either met (n = 31) or did not meet (n = 73) criteria for insomnia disorder as assessed by the Structured Clinical Interview for DSM-5 completed the Effort Expenditure for Rewards Task and provided blood samples for the assessment of C-reactive protein (CRP). Older adults with late-life insomnia showed reduced reward motivation 95% CI [-0.955, -0.569] and reduced reward sensitivity 95% CI [-0.430, -0.075] relative to comparison controls. In secondary exploratory analyses, late-life insomnia was associated with reduced motivation to a greater degree in males than in females 95% CI [0.072, 0.775], particularly when CRP was also elevated 95% CI [0.672, 1.551]. Late-life insomnia is associated with reduced motivation and sensitivity for monetary reward, which suggests insomnia may confer risk for late-life depression by dysregulation of reward mechanisms. Exploratory analyses suggest that older males with insomnia and elevated CRP may be particularly vulnerable to deficits in reward motivation. Although in need of replication and further study, results suggest that interventions that target insomnia or deficits in reward processing may mitigate the risk of depression in nondepressed older adults, especially older males with insomnia." @default.
• W3035030051 created "2020-06-19" @default.
• W3035030051 creator A5003417377 @default.
• W3035030051 creator A5005936736 @default.
• W3035030051 creator A5010333004 @default.
• W3035030051 creator A5033210196 @default.
• W3035030051 creator A5034361112 @default.
• W3035030051 creator A5041892084 @default.
• W3035030051 creator A5057942712 @default.
• W3035030051 creator A5091139449 @default.
• W3035030051 date "2020-06-16" @default.
• W3035030051 modified "2023-09-30" @default.
• W3035030051 title "Motivation and sensitivity to monetary reward in late-life insomnia: moderating role of sex and the inflammatory marker CRP" @default.
• W3035030051 cites W1540653165 @default.
• W3035030051 cites W1778757603 @default.
• W3035030051 cites W1938520684 @default.
• W3035030051 cites W1967113132 @default.
• W3035030051 cites W1968748283 @default.
• W3035030051 cites W1970846977 @default.
• W3035030051 cites W1982924671 @default.
• W3035030051 cites W1997669140 @default.
• W3035030051 cites W2006023779 @default.
• W3035030051 cites W2015859900 @default.
• W3035030051 cites W2042112749 @default.
• W3035030051 cites W2047150345 @default.
• W3035030051 cites W2051703328 @default.
• W3035030051 cites W2054115802 @default.
• W3035030051 cites W2058905991 @default.
• W3035030051 cites W2074669819 @default.
• W3035030051 cites W2089521828 @default.
• W3035030051 cites W2099880548 @default.
• W3035030051 cites W2100087641 @default.
• W3035030051 cites W2104072340 @default.
• W3035030051 cites W2123089523 @default.
• W3035030051 cites W2147865589 @default.
• W3035030051 cites W2155785248 @default.
• W3035030051 cites W2165836892 @default.
• W3035030051 cites W2171640896 @default.
• W3035030051 cites W2196461303 @default.
• W3035030051 cites W2288359005 @default.
• W3035030051 cites W2475319108 @default.
• W3035030051 cites W2504468643 @default.
• W3035030051 cites W2507645382 @default.
• W3035030051 cites W2520703908 @default.
• W3035030051 cites W2548913358 @default.
• W3035030051 cites W2752770718 @default.
• W3035030051 cites W2791771234 @default.
• W3035030051 cites W2793187604 @default.
• W3035030051 cites W2806048455 @default.
• W3035030051 cites W2808599394 @default.
• W3035030051 cites W2809229523 @default.
• W3035030051 cites W2887413242 @default.
• W3035030051 cites W2888582188 @default.
• W3035030051 cites W2899947562 @default.
• W3035030051 cites W2900708943 @default.
• W3035030051 cites W2902980792 @default.
• W3035030051 cites W2918204412 @default.
• W3035030051 cites W2933795674 @default.
• W3035030051 cites W2936486429 @default.
• W3035030051 cites W2941224517 @default.
• W3035030051 cites W4231803356 @default.
• W3035030051 cites W646218571 @default.
• W3035030051 doi "https://doi.org/10.1038/s41386-020-0735-7" @default.
• W3035030051 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7419294" @default.
• W3035030051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32544926" @default.
• W3035030051 hasPublicationYear "2020" @default.
• W3035030051 type Work @default.
• W3035030051 sameAs 3035030051 @default.
• W3035030051 citedByCount "9" @default.
• W3035030051 countsByYear W30350300512022 @default.
• W3035030051 countsByYear W30350300512023 @default.
• W3035030051 crossrefType "journal-article" @default.
• W3035030051 hasAuthorship W3035030051A5003417377 @default.
• W3035030051 hasAuthorship W3035030051A5005936736 @default.
• W3035030051 hasAuthorship W3035030051A5010333004 @default.
• W3035030051 hasAuthorship W3035030051A5033210196 @default.
• W3035030051 hasAuthorship W3035030051A5034361112 @default.
• W3035030051 hasAuthorship W3035030051A5041892084 @default.
• W3035030051 hasAuthorship W3035030051A5057942712 @default.
• W3035030051 hasAuthorship W3035030051A5091139449 @default.
• W3035030051 hasBestOaLocation W30350300511 @default.
• W3035030051 hasConcept C118552586 @default.
• W3035030051 hasConcept C139719470 @default.
• W3035030051 hasConcept C15744967 @default.
• W3035030051 hasConcept C162324750 @default.
• W3035030051 hasConcept C2776867660 @default.
• W3035030051 hasConcept C2781210498 @default.
• W3035030051 hasConcept C70410870 @default.
• W3035030051 hasConceptScore W3035030051C118552586 @default.
• W3035030051 hasConceptScore W3035030051C139719470 @default.
• W3035030051 hasConceptScore W3035030051C15744967 @default.
• W3035030051 hasConceptScore W3035030051C162324750 @default.
• W3035030051 hasConceptScore W3035030051C2776867660 @default.
• W3035030051 hasConceptScore W3035030051C2781210498 @default.
• W3035030051 hasConceptScore W3035030051C70410870 @default.
• W3035030051 hasIssue "10" @default.
• W3035030051 hasLocation W30350300511 @default.
• W3035030051 hasLocation W30350300512 @default.

• next