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- W3035134747 endingPage "11435" @default.
- W3035134747 startingPage "11420" @default.
- W3035134747 abstract "Fragment-based drug discovery is a strategy widely used in both academia and pharmaceutical companies to generate small-molecule protein inhibitors and drug candidates. Among the approaches reported in the literature (growing, linking, and merging), the linking approach theoretically offers the opportunity to rapidly gain in binding energy. Nevertheless, this approach is poorly represented when considering the compounds currently in clinical trials. Here, we report an exhaustive view of the cases published so far in the literature, together with the methods used to identify the two initial fragments either simultaneously or successively. We review the different types of linkers published and discuss how these linkers are designed to obtain the lead compound. Mixing merging and linking methods, where the linker is duplicated from a known inhibitor, appears as an interesting strategy. To reach superadditivity, we propose to grow one of the fragments in order to minimize the distance between the two binders and then link the resulting compounds using flexible alkyl-derived linkers." @default.
- W3035134747 created "2020-06-19" @default.
- W3035134747 creator A5034559960 @default.
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- W3035134747 creator A5063272298 @default.
- W3035134747 creator A5070944824 @default.
- W3035134747 date "2020-06-15" @default.
- W3035134747 modified "2023-10-15" @default.
- W3035134747 title "Fragment Linking Strategies for Structure-Based Drug Design" @default.
- W3035134747 cites W1554612821 @default.
- W3035134747 cites W173882744 @default.
- W3035134747 cites W1965451896 @default.
- W3035134747 cites W1968306630 @default.
- W3035134747 cites W1969314179 @default.
- W3035134747 cites W1971830882 @default.
- W3035134747 cites W1971947883 @default.
- W3035134747 cites W1972091733 @default.
- W3035134747 cites W1972700223 @default.
- W3035134747 cites W1974891315 @default.
- W3035134747 cites W1978876482 @default.
- W3035134747 cites W1980314143 @default.
- W3035134747 cites W1983004361 @default.
- W3035134747 cites W1984596640 @default.
- W3035134747 cites W1986440037 @default.
- W3035134747 cites W1990251351 @default.
- W3035134747 cites W1995311106 @default.
- W3035134747 cites W1996100382 @default.
- W3035134747 cites W2000589020 @default.
- W3035134747 cites W2001091214 @default.
- W3035134747 cites W2006720282 @default.
- W3035134747 cites W2006816012 @default.
- W3035134747 cites W2007272508 @default.
- W3035134747 cites W2013535962 @default.
- W3035134747 cites W2014430663 @default.
- W3035134747 cites W2018109760 @default.
- W3035134747 cites W2021456399 @default.
- W3035134747 cites W2022749059 @default.
- W3035134747 cites W2022901265 @default.
- W3035134747 cites W2028816469 @default.
- W3035134747 cites W2031609935 @default.
- W3035134747 cites W2036005030 @default.
- W3035134747 cites W2036233226 @default.
- W3035134747 cites W2037791377 @default.
- W3035134747 cites W2046258407 @default.
- W3035134747 cites W2047222471 @default.
- W3035134747 cites W2047533107 @default.
- W3035134747 cites W2048245505 @default.
- W3035134747 cites W2058665213 @default.
- W3035134747 cites W2065633704 @default.
- W3035134747 cites W2066378195 @default.
- W3035134747 cites W2073239885 @default.
- W3035134747 cites W2085419794 @default.
- W3035134747 cites W2086827109 @default.
- W3035134747 cites W2088774633 @default.
- W3035134747 cites W2092470007 @default.
- W3035134747 cites W2106941175 @default.
- W3035134747 cites W2113742740 @default.
- W3035134747 cites W2117998993 @default.
- W3035134747 cites W2118112812 @default.
- W3035134747 cites W2118645679 @default.
- W3035134747 cites W2120484655 @default.
- W3035134747 cites W2134486592 @default.
- W3035134747 cites W2135717332 @default.
- W3035134747 cites W2141864949 @default.
- W3035134747 cites W2146910635 @default.
- W3035134747 cites W2150996942 @default.
- W3035134747 cites W2160383282 @default.
- W3035134747 cites W2168632005 @default.
- W3035134747 cites W2172242534 @default.
- W3035134747 cites W2297303230 @default.
- W3035134747 cites W244796693 @default.
- W3035134747 cites W2461116783 @default.
- W3035134747 cites W2467779447 @default.
- W3035134747 cites W2508139923 @default.
- W3035134747 cites W2521624147 @default.
- W3035134747 cites W2527832308 @default.
- W3035134747 cites W2588056590 @default.
- W3035134747 cites W2588240447 @default.
- W3035134747 cites W2607720215 @default.
- W3035134747 cites W2610429468 @default.
- W3035134747 cites W2788282464 @default.
- W3035134747 cites W2793848865 @default.
- W3035134747 cites W2799299843 @default.
- W3035134747 cites W2803845601 @default.
- W3035134747 cites W2898517788 @default.
- W3035134747 cites W2915245694 @default.
- W3035134747 cites W2971116291 @default.
- W3035134747 cites W4211027922 @default.
- W3035134747 cites W4233548753 @default.
- W3035134747 cites W4362017974 @default.
- W3035134747 doi "https://doi.org/10.1021/acs.jmedchem.0c00242" @default.
- W3035134747 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32539387" @default.
- W3035134747 hasPublicationYear "2020" @default.
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