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- W3035138898 endingPage "934" @default.
- W3035138898 startingPage "922" @default.
- W3035138898 abstract "Abstract Aberrant MET signaling can drive tumorigenesis in several cancer types through a variety of molecular mechanisms including MET gene amplification, mutation, rearrangement, and overexpression. Improvements in biomarker discovery and testing have more recently enabled the selection of patients with MET-dependent cancers for treatment with potent, specific, and novel MET-targeting therapies. We review the known oncologic processes that activate MET, discuss therapeutic strategies for MET-dependent malignancies, and highlight emerging challenges in acquired drug resistance in these cancers. Significance: Increasing evidence supports the use of MET-targeting therapies in biomarker-selected cancers that harbor molecular alterations in MET. Diverse mechanisms of resistance to MET inhibitors will require the development of novel strategies to delay and overcome drug resistance." @default.
- W3035138898 created "2020-06-19" @default.
- W3035138898 creator A5048675362 @default.
- W3035138898 creator A5065133327 @default.
- W3035138898 creator A5079325672 @default.
- W3035138898 creator A5086249998 @default.
- W3035138898 date "2020-07-01" @default.
- W3035138898 modified "2023-10-17" @default.
- W3035138898 title "Targeting<i>MET</i>Dysregulation in Cancer" @default.
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