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- W3035162005 abstract "Duchenne muscular dystrophy (DMD) is one of the fatal X-linked disorders that are characterized by progressive muscle weakness and occur due to mutation in the largest human gene known as the DMD gene which encodes dystrophin protein that is mandatory for keeping the muscles structurally and functionally intact. The disease always affects boys (1 from every ~5000), and in some cases the female carriers are symptomatic. The disease usually leads to impairment in cardiac and pulmonary functions leading to the death of the patients in very young ages. Understanding DMD through precise molecular diagnosis will aid in determining the suitable therapeutic approach for the cases like designing exon-skipping antisense oligonucleotides (AOs) or stem cell-based therapies in conjunction with gene editing techniques (CRISPR/Cas9). Such therapies can correct the genetic defect in the DMD gene and ameliorate the symptoms. In this chapter, we will illustrate the past and current strategies for DMD disease treatment." @default.
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- W3035162005 date "2020-12-23" @default.
- W3035162005 modified "2023-10-01" @default.
- W3035162005 title "Duchenne Muscular Dystrophy (DMD) Treatment: Past and Present Perspectives" @default.
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- W3035162005 doi "https://doi.org/10.5772/intechopen.92765" @default.
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