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- W3035168074 abstract "ABSTRACT During infections with protozoan parasites or virus, T cell immunosuppression is generated simultaneously with a high B cell activation. Here, we show that in T. cruzi infection, all plasmablasts detected had higher surface expression of PD-L1, than other mononuclear cells. PD-L1 hi plasmablasts were induced in vivo in an antigen-specific manner and required help from Bcl-6 + CD4 + T cells. PD-L1 hi expression was not a characteristic of all antibody-secreting cells since plasma cells found during the chronic phase of infection express PD-L1 but at lower levels. PD-L1 hi plasmablasts were also present in mice infected with Plasmodium or with lymphocytic choriomeningitis virus, but not in mice with autoimmune disorders or immunized with T cell-dependent antigens. PD-L1 hi plasmablasts suppressed T cell response, via PD-L1, in vitro and in vivo . Thus, this study reveals that extrafollicular PD-L1 hi plasmablasts, which precede the germinal center (CG) response, are a suppressive population in infections that may influence T cell response. Brief summary Pathogens develop different strategies to settle in the host. We identified a plasmablats population induced by pathogens in acute infections which suppress T cell response." @default.
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- W3035168074 date "2020-06-12" @default.
- W3035168074 modified "2023-10-01" @default.
- W3035168074 title "PD-L1hi plasmablasts limit the T cell response during the acute phase of parasite infections" @default.
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- W3035168074 doi "https://doi.org/10.1101/2020.06.10.142067" @default.
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