Matches in SemOpenAlex for { <https://semopenalex.org/work/W3035194220> ?p ?o ?g. }
- W3035194220 abstract "The formation of spatiotemporal patterns of gene expression is frequently guided by gradients of diffusible signaling molecules. The toggle switch subnetwork, composed of two cross-repressing transcription factors, is a common component of gene regulatory networks in charge of patterning, converting the continuous information provided by the gradient into discrete abutting stripes of gene expression. We present a synthetic biology framework to understand and characterize the spatiotemporal patterning properties of the toggle switch. To this end, we built a synthetic toggle switch controllable by diffusible molecules in Escherichia coli. We analyzed the patterning capabilities of the circuit by combining quantitative measurements with a mathematical reconstruction of the underlying dynamical system. The toggle switch can produce robust patterns with sharp boundaries, governed by bistability and hysteresis. We further demonstrate how the hysteresis, position, timing, and precision of the boundary can be controlled, highlighting the dynamical flexibility of the circuit." @default.
- W3035194220 created "2020-06-19" @default.
- W3035194220 creator A5028014828 @default.
- W3035194220 creator A5067881972 @default.
- W3035194220 creator A5083080645 @default.
- W3035194220 date "2020-06-01" @default.
- W3035194220 modified "2023-10-18" @default.
- W3035194220 title "Controlling spatiotemporal pattern formation in a concentration gradient with a synthetic toggle switch" @default.
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- W3035194220 doi "https://doi.org/10.15252/msb.20199361" @default.
- W3035194220 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7290156" @default.
- W3035194220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32529808" @default.
- W3035194220 hasPublicationYear "2020" @default.
- W3035194220 type Work @default.