Matches in SemOpenAlex for { <https://semopenalex.org/work/W3035202433> ?p ?o ?g. }
- W3035202433 endingPage "113042" @default.
- W3035202433 startingPage "113042" @default.
- W3035202433 abstract "Abstract Ethnopharmacological relevance Croton urucurana Baill. (Euphorbiaceae) is a plant used in Brazilian popular medicine for the treatment of wound healing, inflammatory diseases, gastritis, infections, and hemorrhoids. Aim The present study aimed to evaluate the in vivo wound healing activity of an ointment based on ethanolic extract of C. urucurana stem bark, at concentrations of 5% and 10%, and to relate it with compounds that could be associated with this activity. Materials and methods Analyses by FIA-ESI-IT-MSn were carried out to investigate the chemical composition of C. urucurana. Knockout IL-10 (n = 60) mice and wild type C57 (n = 12) mice were separated into 6 groups to evaluate the wound healing activity. Knockout IL-10 mice: SAL (0.9% saline); BAS (ointment base); SS (1% silver sulfadiazine); CR1 (ointment with extract of C. urucurana 5%); CR2 (ointment with extract of C. urucurana 10%); and wild mice C57: SALC57 (Saline 0.9%). A circular wound with 10 mm in diameter was generated on the dorsal of the animals. Tissue specimen of the wounds were removed on days 7 and 14 of the treatment for histopathological, oxidative status and analyses of pro-and anti-inflammatory cytokines in scar tissue. Results In the phytochemical profile, twelve proanthocyanidins were identified (in the form of monomers, dimers, trimers, and tetramers), based on (epi)catechin and (epi)gallocatechin. Furthermore, two quercetin derivatives and two alkaloids were detected. The groups treated with CR1 and CR2 ointments presented higher rate of wound closure, increased total number of cells, mast cells, blood vessels and higher deposition of type III and I collagen. In addition, they showed increased amount of pro-inflammatory cytokines (IL- 2 and IFN-γ), and anti-inflmatory cytokines (IL-4), on the 7th day of treatment. Conclusion The results presented support the popular use of preparations based on the bark of C. urucurana as a healing compound." @default.
- W3035202433 created "2020-06-19" @default.
- W3035202433 creator A5000126737 @default.
- W3035202433 creator A5010215972 @default.
- W3035202433 creator A5012760689 @default.
- W3035202433 creator A5018206064 @default.
- W3035202433 creator A5029740930 @default.
- W3035202433 creator A5030319687 @default.
- W3035202433 creator A5055073510 @default.
- W3035202433 creator A5073420846 @default.
- W3035202433 date "2020-10-01" @default.
- W3035202433 modified "2023-10-18" @default.
- W3035202433 title "Croton urucurana Baillon stem bark ointment accelerates the closure of cutaneous wounds in knockout IL-10 mice" @default.
- W3035202433 cites W1493111032 @default.
- W3035202433 cites W1530955222 @default.
- W3035202433 cites W1618337835 @default.
- W3035202433 cites W1750728818 @default.
- W3035202433 cites W1762431693 @default.
- W3035202433 cites W1775749144 @default.
- W3035202433 cites W1914615969 @default.
- W3035202433 cites W1931359360 @default.
- W3035202433 cites W1964127298 @default.
- W3035202433 cites W1969232926 @default.
- W3035202433 cites W1971981119 @default.
- W3035202433 cites W1972009654 @default.
- W3035202433 cites W1982660499 @default.
- W3035202433 cites W1986308133 @default.
- W3035202433 cites W1990295999 @default.
- W3035202433 cites W1991889637 @default.
- W3035202433 cites W2008615895 @default.
- W3035202433 cites W2011727226 @default.
- W3035202433 cites W2014395240 @default.
- W3035202433 cites W2014469792 @default.
- W3035202433 cites W2015359629 @default.
- W3035202433 cites W2018987086 @default.
- W3035202433 cites W2019732568 @default.
- W3035202433 cites W2024623214 @default.
- W3035202433 cites W2024655771 @default.
- W3035202433 cites W2028141168 @default.
- W3035202433 cites W2036814788 @default.
- W3035202433 cites W2041591721 @default.
- W3035202433 cites W2042501392 @default.
- W3035202433 cites W2044219187 @default.
- W3035202433 cites W2048689249 @default.
- W3035202433 cites W2049150736 @default.
- W3035202433 cites W2053398175 @default.
- W3035202433 cites W2059327215 @default.
- W3035202433 cites W2059963928 @default.
- W3035202433 cites W2067599801 @default.
- W3035202433 cites W2080609998 @default.
- W3035202433 cites W2083269115 @default.
- W3035202433 cites W2084065253 @default.
- W3035202433 cites W2084375915 @default.
- W3035202433 cites W2092326765 @default.
- W3035202433 cites W2114688451 @default.
- W3035202433 cites W2114861231 @default.
- W3035202433 cites W2117575119 @default.
- W3035202433 cites W2126757700 @default.
- W3035202433 cites W2132360453 @default.
- W3035202433 cites W2135568957 @default.
- W3035202433 cites W2140730215 @default.
- W3035202433 cites W2154469550 @default.
- W3035202433 cites W2206396087 @default.
- W3035202433 cites W2223932693 @default.
- W3035202433 cites W2288620160 @default.
- W3035202433 cites W2290044714 @default.
- W3035202433 cites W2301118721 @default.
- W3035202433 cites W2353982544 @default.
- W3035202433 cites W2514892365 @default.
- W3035202433 cites W2537745350 @default.
- W3035202433 cites W2548516545 @default.
- W3035202433 cites W2566412311 @default.
- W3035202433 cites W2620280614 @default.
- W3035202433 cites W2754916592 @default.
- W3035202433 cites W2756388379 @default.
- W3035202433 cites W2767004508 @default.
- W3035202433 cites W2791749866 @default.
- W3035202433 cites W2797676345 @default.
- W3035202433 cites W2799671456 @default.
- W3035202433 cites W2804508211 @default.
- W3035202433 cites W2823834218 @default.
- W3035202433 cites W2883076690 @default.
- W3035202433 cites W2901409942 @default.
- W3035202433 cites W2921606558 @default.
- W3035202433 cites W4235220380 @default.
- W3035202433 doi "https://doi.org/10.1016/j.jep.2020.113042" @default.
- W3035202433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32531412" @default.
- W3035202433 hasPublicationYear "2020" @default.
- W3035202433 type Work @default.
- W3035202433 sameAs 3035202433 @default.
- W3035202433 citedByCount "9" @default.
- W3035202433 countsByYear W30352024332021 @default.
- W3035202433 countsByYear W30352024332022 @default.
- W3035202433 countsByYear W30352024332023 @default.
- W3035202433 crossrefType "journal-article" @default.
- W3035202433 hasAuthorship W3035202433A5000126737 @default.
- W3035202433 hasAuthorship W3035202433A5010215972 @default.
- W3035202433 hasAuthorship W3035202433A5012760689 @default.