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- W3035214612 abstract "Abstract Mitogenic signals that regulate cell division often proceed through multi-enzyme assemblies within defined intracellular compartments. The anchoring protein Gravin restricts the action of mitotic kinases and cell-cycle effectors to defined mitotic structures. In this report we discover that genetic deletion of Gravin disrupts proper accumulation and asymmetric distribution of γ-tubulin during mitosis. We utilize a new precision pharmacology tool, Local Kinase Inhibition (LoKI), to inhibit the Gravin binding partner polo-like kinase 1 (Plk1) at spindle poles. Using a combination of gene-editing approaches, quantitative imaging, and biochemical assays we provide evidence that disruption of local Plk1 signaling underlies the γ-tubulin distribution defects observed with Gravin loss. Our study uncovers a new role for Gravin in coordinating γ-tubulin recruitment during mitosis and illuminates the mechanism by which signaling enzymes regulate this process at a distinct subcellular location." @default.
- W3035214612 created "2020-06-19" @default.
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- W3035214612 date "2020-06-12" @default.
- W3035214612 modified "2023-10-18" @default.
- W3035214612 title "Gravin-associated kinase signaling networks coordinate γ-tubulin organization at mitotic spindle poles" @default.
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- W3035214612 doi "https://doi.org/10.1101/2020.06.12.148171" @default.
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