Matches in SemOpenAlex for { <https://semopenalex.org/work/W3035237580> ?p ?o ?g. }
- W3035237580 abstract "Abstract Zinc-α2-glycoprotein (ZAG), as an adipokine, plays an important role in lipid metabolism. However, its influence on whole gene expression profile in adipose tissue is not known. Under stress condition, how ZAG affects the lipid metabolism is also unclear. Therefore, in this study ZAG systemic knockout (KO) mice were used as a model to reveal the genes expression profile in visceral fat tissues of ZAG KO mice and wild-type mice by genome-wide microarray screening. Then dexamethasone (DEX) was used to explore the effect of ZAG deletion on body fat metabolism under stress. Our results showed that 179 genes were differentially expressed more than 1.5 times between ZAG KO mice and wild type mice, of which 26 genes were upregulated dramatically and 153 genes were significantly downregulated. Under DEX simulated stress, ZAG systemic knockout in vivo resulted in a markedly decrease of triglycerides (TG) and nonesterified fatty acid (NEFA) content in in plasma. Similarly, for lipid catabolism, ZAG KO led to a significant increase of phosphorylated HSL (p-HSL) protein and a rising tendency of adipose triglyceride lipase (ATGL) protein relative to those of the DEX group. For lipid anabolism, fatty acid synthase (FAS) and adiponectin protein expression in visceral fat rose notably in ZAG KO mice after DEX treatment. In conclusion, ZAG knockout can affect the gene expression profile of adipose tissue, reduce elevated TG and NEFA levels in plasma, and alter lipid metabolism under DEX treatment. These findings provide new insights into the mechanism of lipid metabolic disorders in response to stress." @default.
- W3035237580 created "2020-06-19" @default.
- W3035237580 creator A5036911553 @default.
- W3035237580 creator A5045398992 @default.
- W3035237580 creator A5068420402 @default.
- W3035237580 creator A5071265991 @default.
- W3035237580 creator A5073641270 @default.
- W3035237580 creator A5076803183 @default.
- W3035237580 date "2020-06-15" @default.
- W3035237580 modified "2023-09-24" @default.
- W3035237580 title "Zinc-α2-Glycoprotein Knockout Influenced Genes Expression Profile in Adipose Tissue and Decreased the Lipid Mobilizing After Dexamethasone Treatment in Mice" @default.
- W3035237580 cites W108612960 @default.
- W3035237580 cites W1968634370 @default.
- W3035237580 cites W1980867583 @default.
- W3035237580 cites W1984789703 @default.
- W3035237580 cites W1985336161 @default.
- W3035237580 cites W1993358076 @default.
- W3035237580 cites W1994596431 @default.
- W3035237580 cites W1996423442 @default.
- W3035237580 cites W1999429145 @default.
- W3035237580 cites W2004456757 @default.
- W3035237580 cites W2019642669 @default.
- W3035237580 cites W2031352461 @default.
- W3035237580 cites W2037785002 @default.
- W3035237580 cites W2044047399 @default.
- W3035237580 cites W2049962336 @default.
- W3035237580 cites W2051108350 @default.
- W3035237580 cites W2068165868 @default.
- W3035237580 cites W2070854038 @default.
- W3035237580 cites W2073665119 @default.
- W3035237580 cites W2083055973 @default.
- W3035237580 cites W2083056430 @default.
- W3035237580 cites W2094997711 @default.
- W3035237580 cites W2107804834 @default.
- W3035237580 cites W2110839026 @default.
- W3035237580 cites W2115274616 @default.
- W3035237580 cites W2119778893 @default.
- W3035237580 cites W2128352893 @default.
- W3035237580 cites W2152727172 @default.
- W3035237580 cites W2155432449 @default.
- W3035237580 cites W2167475438 @default.
- W3035237580 cites W2275265220 @default.
- W3035237580 cites W2418405651 @default.
- W3035237580 cites W2419289283 @default.
- W3035237580 cites W2547217201 @default.
- W3035237580 cites W2785142570 @default.
- W3035237580 cites W2884949921 @default.
- W3035237580 doi "https://doi.org/10.1055/a-1186-0649" @default.
- W3035237580 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32542628" @default.
- W3035237580 hasPublicationYear "2020" @default.
- W3035237580 type Work @default.
- W3035237580 sameAs 3035237580 @default.
- W3035237580 citedByCount "3" @default.
- W3035237580 countsByYear W30352375802021 @default.
- W3035237580 countsByYear W30352375802022 @default.
- W3035237580 crossrefType "journal-article" @default.
- W3035237580 hasAuthorship W3035237580A5036911553 @default.
- W3035237580 hasAuthorship W3035237580A5045398992 @default.
- W3035237580 hasAuthorship W3035237580A5068420402 @default.
- W3035237580 hasAuthorship W3035237580A5071265991 @default.
- W3035237580 hasAuthorship W3035237580A5073641270 @default.
- W3035237580 hasAuthorship W3035237580A5076803183 @default.
- W3035237580 hasConcept C126322002 @default.
- W3035237580 hasConcept C134018914 @default.
- W3035237580 hasConcept C140985366 @default.
- W3035237580 hasConcept C170493617 @default.
- W3035237580 hasConcept C171089720 @default.
- W3035237580 hasConcept C182704531 @default.
- W3035237580 hasConcept C185592680 @default.
- W3035237580 hasConcept C194832188 @default.
- W3035237580 hasConcept C2776782570 @default.
- W3035237580 hasConcept C2776991927 @default.
- W3035237580 hasConcept C2777062983 @default.
- W3035237580 hasConcept C2777391703 @default.
- W3035237580 hasConcept C2779306644 @default.
- W3035237580 hasConcept C2779772378 @default.
- W3035237580 hasConcept C2780613262 @default.
- W3035237580 hasConcept C2781227529 @default.
- W3035237580 hasConcept C4733338 @default.
- W3035237580 hasConcept C48289651 @default.
- W3035237580 hasConcept C511355011 @default.
- W3035237580 hasConcept C543025807 @default.
- W3035237580 hasConcept C55493867 @default.
- W3035237580 hasConcept C62231903 @default.
- W3035237580 hasConcept C71924100 @default.
- W3035237580 hasConcept C86803240 @default.
- W3035237580 hasConcept C96942376 @default.
- W3035237580 hasConceptScore W3035237580C126322002 @default.
- W3035237580 hasConceptScore W3035237580C134018914 @default.
- W3035237580 hasConceptScore W3035237580C140985366 @default.
- W3035237580 hasConceptScore W3035237580C170493617 @default.
- W3035237580 hasConceptScore W3035237580C171089720 @default.
- W3035237580 hasConceptScore W3035237580C182704531 @default.
- W3035237580 hasConceptScore W3035237580C185592680 @default.
- W3035237580 hasConceptScore W3035237580C194832188 @default.
- W3035237580 hasConceptScore W3035237580C2776782570 @default.
- W3035237580 hasConceptScore W3035237580C2776991927 @default.
- W3035237580 hasConceptScore W3035237580C2777062983 @default.
- W3035237580 hasConceptScore W3035237580C2777391703 @default.
- W3035237580 hasConceptScore W3035237580C2779306644 @default.