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- W3035242014 abstract "Abstract Fenton reaction‐mediated chemodynamic therapy (CDT) can kill cancer cells via the conversion of H 2 O 2 to highly toxic HO•. However, problems such as insufficient H 2 O 2 levels in the tumor tissue and low Fenton reaction efficiency severely limit the performance of CDT. Here, the prodrug tirapazamine (TPZ)‐loaded human serum albumin (HSA)–glucose oxidase (GOx) mixture is prepared and modified with a metal–polyphenol network composed of ferric ions (Fe 3+ ) and tannic acid (TA), to obtain a self‐amplified nanoreactor termed HSA–GOx–TPZ–Fe 3+ –TA (HGTFT) for sustainable and cascade cancer therapy with exogenous H 2 O 2 production and TA‐accelerated Fe 3+ /Fe 2+ conversion. The HGTFT nanoreactor can efficiently convert oxygen into HO• for CDT, consume glucose for starvation therapy, and provide a hypoxic environment for TPZ radical‐mediated chemotherapy. Besides, it is revealed that the nanoreactor can significantly elevate the intracellular reactive oxygen species content and hypoxia level, decrease the intracellular glutathione content, and release metal ions in the tumors for metal ion interference therapy (also termed “ion‐interference therapy” or “metal ion therapy”). Further, the nanoreactor can also increase the tumor’s hypoxia level and efficiently inhibit tumor growth. It is believed that this tumor microenvironment‐regulable nanoreactor with sustainable and cascade anticancer performance and excellent biosafety represents an advance in nanomedicine." @default.
- W3035242014 created "2020-06-19" @default.
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- W3035242014 date "2020-06-15" @default.
- W3035242014 modified "2023-10-11" @default.
- W3035242014 title "A Glucose/Oxygen‐Exhausting Nanoreactor for Starvation‐ and Hypoxia‐Activated Sustainable and Cascade Chemo‐Chemodynamic Therapy" @default.
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- W3035242014 doi "https://doi.org/10.1002/smll.202000897" @default.
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