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- W3035245759 abstract "The development of cost-efficient, sensitive and specific methods to detect amyloid-beta 42 ( $text{A}beta 42$ ) biomarkers in cerebrospinal fluid and serum-samples is of considerable interest to enable early and reliable diagnosis of Alzheimer’s disease as a precondition for future disease-modifying therapies. This paper presents a reduced graphene oxide field effect transistor (r-GO FET) for label free ultrasensitive detection of an $text{A}beta 42$ -biomarker with RNA aptamer. The channel in the device was formed by reduction of graphene oxide nanosheets by self-assembly process. As a result, the interaction between $text{A}beta 42$ and RNA aptamer on the surface of r-GO channel caused a linear response in the shift of the gate voltage ( $text{V}_{mathbf {TG}}$ ) where the minimum conductivity occurs. The r-GO FET can detect the biomarker in range of 1ng/ml to 1pg/ml at pH 7.4 with high specificity. The developed r-GO FET is a low-cost, highly sensitive and selective method for detecting tiny concentrations of $text{A}beta 42$ , which would also enable measurements in serum-samples." @default.
- W3035245759 created "2020-06-19" @default.
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- W3035245759 date "2020-11-01" @default.
- W3035245759 modified "2023-09-23" @default.
- W3035245759 title "Graphene Field Effect Transistor Biosensors Based on Aptamer for Amyloid-<i>β</i> Detection" @default.
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- W3035245759 doi "https://doi.org/10.1109/jsen.2020.3000583" @default.
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