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- W3035324053 abstract "Access to an electronic data warehouse (EDW) of psoriasis patient data is a rich source of information for big data analytics. University Hospitals Cleveland Medical Center (UHCMC) employs a central data archive obtained from various primary sources (inpatient, outpatient, billing etc…). Psoriasis is increasingly being regarded as a systemic inflammatory disorder with various comorbid diseases associated with a high burden of disease. We examined whether or not severe psoriasis patients have a greater associated cost-of-illness and determined if any unique patient cohorts (endotype) could be associated with psoriatic patients with differing burden rates. An EDW query was used to identify psoriasis patients who have seen providers at UHCMC and associated hospitals and clinics. The EDW pulls data from EMR billing systems and scheduling systems and includes data such as charges, diagnoses, medications, patient demographics, payer information, lab results, and provider orders. Charge data from 52 psoriasis patients was analyzed and separated into four categories: procedures, ambulatory, testing, and hospitalizations. Extensive transcriptomic (blood), flow cytometry, and clinical information were collected from these patients as part of their participation in the Psoriasis Center of Research Translation (CORT). Total cost per patient was significantly correlated (r=0.35, p=0.0115) with the percentage of circulating proinflammatory intermediate monocytes. In addition, total costs were also significantly correlated with the number of therapies patients failed (r=0.378, p=0.0056) and total burden of disease (r=0.394, p=0.0035). Thus, total charges may accurately reflect correlative biomarkers with psoriasis severity." @default.
- W3035324053 created "2020-06-19" @default.
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- W3035324053 date "2020-07-01" @default.
- W3035324053 modified "2023-09-27" @default.
- W3035324053 title "010 Correlation of psoriasis severity with burden of disease cost in psoriatic patients" @default.
- W3035324053 doi "https://doi.org/10.1016/j.jid.2020.03.012" @default.
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