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• W3035328121 endingPage "e0234507" @default.
• W3035328121 startingPage "e0234507" @default.
• W3035328121 abstract "Introduction Maximal oxygen uptake () is a measure of cardiorespiratory fitness often used to monitor changes in fitness during and after treatment in cancer patients. There is, however, limited knowledge in how criteria verifying work for patients newly diagnosed with cancer. Therefore, the aim of this study was to describe the prevalence of fulfillment of typical criteria verifying and to investigate the associations between the criteria and the test leader’s evaluation whether a test was performed “to exhaustion”. An additional aim was to establish new cut-points within the associated criteria. Methods From the Phys-Can randomized controlled trial, 535 patients (59 ±12 years) newly diagnosed with breast (79%), prostate (17%) or colorectal cancer (4%) performed an incremental test on a treadmill. The test was performed before starting (neo-)adjuvant treatment and an exercise intervention. Fulfillment of different cut-points within typical criteria verifying was described. The dependent key variables included in the initial bivariate analysis were achievement of a plateau, peak values for maximal heart rate, respiratory exchange ratio (RER), the patients’ rating of perceived exertion on Borg’s scale6-20 and peak breathing frequency (fR). A receiver operating characteristic analysis was performed to establish cut-points for variables associated with the test leader’s evaluation. Last, a cross-validation of the cut-points found in the receiver operating characteristic analysis was performed on a comparable sample of cancer patients (n = 80). Results The criteria RERpeak (<0.001), Borg’s RPE (<0.001) and fR peak (p = 0.018) were associated with the test leader’s evaluation of whether a test was defined as “to exhaustion”. The cut-points that best predicted the test leader’s evaluation were RER ≥ 1.14, RPE ≥ 18 and fR ≥ 40. Maximal heart rate and plateau was not associated with the test leader’s evaluation. Conclusion We recommend a focus on RER (in the range between ≥1.1 and ≥1.15) and RPE (≥17 or ≥18) in addition to the test leader’s evaluation. Additionally, a fR peak of ≥40 breaths/min may be a cut-point to help the test leader evaluate the degree of exhaustion. However, more research is needed to verify our findings, and to investigate how these criteria will work within a population that are undergoing or finished with cancer treatment." @default.
• W3035328121 created "2020-06-19" @default.
• W3035328121 creator A5011992365 @default.
• W3035328121 creator A5083059837 @default.
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• W3035328121 date "2020-06-11" @default.
• W3035328121 modified "2023-10-18" @default.
• W3035328121 title "Criteria for the determination of maximal oxygen uptake in patients newly diagnosed with cancer: Baseline data from the randomized controlled trial of physical training and cancer (Phys-Can)" @default.
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• W3035328121 doi "https://doi.org/10.1371/journal.pone.0234507" @default.
• W3035328121 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7289625" @default.
• W3035328121 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32526771" @default.
• W3035328121 hasPublicationYear "2020" @default.
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