FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3035334811> ?p ?o ?g. }

• W3035334811 abstract "Abstract Background Increasing evidence supports the role of soluble inflammatory mediators in the pathogenesis of refractory temporal lobe epilepsy (TLE). Hippocampal sclerosis (HS) is a well-described pathohistological abnormality in TLE. The association of proinflammatory cytokines with epileptic disease profiles is well established; however, the potential significance of circulating interleukin 10 (IL-10), particularly in TLE-associated HS, is still poorly understood. Therefore, taking into consideration the neuroprotective and anticonvulsive effects of IL-10, we performed this study to examine the role of the plasma levels of IL-10 in patients with TLE with HS (TLE + HS), TLE without HS (TLE-HS) and with other types of epilepsy. Methods This study included 270 patients with refractory epilepsy who were classified into four groups: i) 34 patients with TLE + HS, ii) 105 patients with TLE-HS, iii) 95 patients with extra-TLE (XLE) and iv) 36 patients with idiopathic generalized epilepsy (IGE). The plasma IL-10 levels were quantified using a commercially available enzyme-linked immunosorbent assay (ELISA). Results IL-10 levels were significantly lower in TLE + HS than in TLE-HS ( p = 0.013). In a subgroup of TLE-HS patients who had seizures 1 month before sampling, patients with seizures had significantly higher IL-10 levels than patients who were seizure-free ( p = 0.039). Among a small group ( n = 15) of non-refractory TLE-HS patients, IL-10 levels showed a moderate negative correlation with the duration of epilepsy ( r = − 0.585, p = 0.023). Conclusions This study demonstrated that chronically reduced levels of plasma IL-10 were associated with HS in TLE patients, suggesting that there was an inadequate systemic anti-inflammatory immune response. These results could provide new biological insights into the pathophysiology of HS in TLE. We also found that the production of IL-10 could be affected by the seizure frequency and declined concomitantly with increased disease durations. Therefore, the measurement of plasma IL-10 may have diagnostic value as a biomarker for stratifying TLE + HS from other epilepsy types or as a marker of disease progression towards a progressive form of epilepsy." @default.
• W3035334811 created "2020-06-19" @default.
• W3035334811 creator A5001051208 @default.
• W3035334811 creator A5009512380 @default.
• W3035334811 creator A5016268752 @default.
• W3035334811 creator A5027609885 @default.
• W3035334811 creator A5027813085 @default.
• W3035334811 creator A5029143758 @default.
• W3035334811 creator A5032055241 @default.
• W3035334811 creator A5048705599 @default.
• W3035334811 date "2020-06-12" @default.
• W3035334811 modified "2023-10-06" @default.
• W3035334811 title "Chronically reduced IL-10 plasma levels are associated with hippocampal sclerosis in temporal lobe epilepsy patients" @default.
• W3035334811 cites W1550524407 @default.
• W3035334811 cites W1561207348 @default.
• W3035334811 cites W1920696238 @default.
• W3035334811 cites W1967052290 @default.
• W3035334811 cites W1971963029 @default.
• W3035334811 cites W1988681342 @default.
• W3035334811 cites W1996918660 @default.
• W3035334811 cites W2013335100 @default.
• W3035334811 cites W2020680492 @default.
• W3035334811 cites W2026183163 @default.
• W3035334811 cites W2041093905 @default.
• W3035334811 cites W2055394920 @default.
• W3035334811 cites W2082833331 @default.
• W3035334811 cites W2106684817 @default.
• W3035334811 cites W2128463839 @default.
• W3035334811 cites W2132397635 @default.
• W3035334811 cites W2147337980 @default.
• W3035334811 cites W2179312044 @default.
• W3035334811 cites W2181909228 @default.
• W3035334811 cites W2510084102 @default.
• W3035334811 cites W2531406618 @default.
• W3035334811 cites W2557174471 @default.
• W3035334811 cites W2763334727 @default.
• W3035334811 cites W2763356684 @default.
• W3035334811 cites W2773881388 @default.
• W3035334811 cites W2884335847 @default.
• W3035334811 cites W2902460584 @default.
• W3035334811 cites W2942591730 @default.
• W3035334811 cites W2954314772 @default.
• W3035334811 cites W2955578722 @default.
• W3035334811 cites W4211096313 @default.
• W3035334811 cites W4232918452 @default.
• W3035334811 doi "https://doi.org/10.1186/s12883-020-01825-x" @default.
• W3035334811 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7291453" @default.
• W3035334811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32532251" @default.
• W3035334811 hasPublicationYear "2020" @default.
• W3035334811 type Work @default.
• W3035334811 sameAs 3035334811 @default.
• W3035334811 citedByCount "18" @default.
• W3035334811 countsByYear W30353348112021 @default.
• W3035334811 countsByYear W30353348112022 @default.
• W3035334811 countsByYear W30353348112023 @default.
• W3035334811 crossrefType "journal-article" @default.
• W3035334811 hasAuthorship W3035334811A5001051208 @default.
• W3035334811 hasAuthorship W3035334811A5009512380 @default.
• W3035334811 hasAuthorship W3035334811A5016268752 @default.
• W3035334811 hasAuthorship W3035334811A5027609885 @default.
• W3035334811 hasAuthorship W3035334811A5027813085 @default.
• W3035334811 hasAuthorship W3035334811A5029143758 @default.
• W3035334811 hasAuthorship W3035334811A5032055241 @default.
• W3035334811 hasAuthorship W3035334811A5048705599 @default.
• W3035334811 hasBestOaLocation W30353348111 @default.
• W3035334811 hasConcept C118552586 @default.
• W3035334811 hasConcept C126322002 @default.
• W3035334811 hasConcept C134018914 @default.
• W3035334811 hasConcept C164027704 @default.
• W3035334811 hasConcept C16568411 @default.
• W3035334811 hasConcept C2776914184 @default.
• W3035334811 hasConcept C2777597344 @default.
• W3035334811 hasConcept C2778186239 @default.
• W3035334811 hasConcept C2780942790 @default.
• W3035334811 hasConcept C2781099131 @default.
• W3035334811 hasConcept C2781161787 @default.
• W3035334811 hasConcept C39920043 @default.
• W3035334811 hasConcept C71924100 @default.
• W3035334811 hasConcept C90924648 @default.
• W3035334811 hasConceptScore W3035334811C118552586 @default.
• W3035334811 hasConceptScore W3035334811C126322002 @default.
• W3035334811 hasConceptScore W3035334811C134018914 @default.
• W3035334811 hasConceptScore W3035334811C164027704 @default.
• W3035334811 hasConceptScore W3035334811C16568411 @default.
• W3035334811 hasConceptScore W3035334811C2776914184 @default.
• W3035334811 hasConceptScore W3035334811C2777597344 @default.
• W3035334811 hasConceptScore W3035334811C2778186239 @default.
• W3035334811 hasConceptScore W3035334811C2780942790 @default.
• W3035334811 hasConceptScore W3035334811C2781099131 @default.
• W3035334811 hasConceptScore W3035334811C2781161787 @default.
• W3035334811 hasConceptScore W3035334811C39920043 @default.
• W3035334811 hasConceptScore W3035334811C71924100 @default.
• W3035334811 hasConceptScore W3035334811C90924648 @default.
• W3035334811 hasIssue "1" @default.
• W3035334811 hasLocation W30353348111 @default.
• W3035334811 hasLocation W30353348112 @default.
• W3035334811 hasLocation W30353348113 @default.
• W3035334811 hasLocation W30353348114 @default.
• W3035334811 hasLocation W30353348115 @default.
• W3035334811 hasOpenAccess W3035334811 @default.

• next