Matches in SemOpenAlex for { <https://semopenalex.org/work/W3035339434> ?p ?o ?g. }
- W3035339434 endingPage "20342" @default.
- W3035339434 startingPage "20338" @default.
- W3035339434 abstract "DNA-encoded combinatorial synthesis provides efficient and dense coverage of chemical space around privileged molecular structures. The indole side chain of tryptophan plays a prominent role in key, or hot spot, regions of protein-protein interactions. A DNA-encoded combinatorial peptoid library was designed based on the Ugi four-component reaction by employing tryptophan-mimetic indole side chains to probe the surface of target proteins. Several peptoids were synthesized on a chemically stable hexathymidine adapter oligonucleotide hexT, encoded by DNA sequences, and substituted by azide-alkyne cycloaddition to yield a library of 8112 molecules. Selection experiments for the tumor-relevant proteins MDM2 and TEAD4 yielded MDM2 binders and a novel class of TEAD-YAP interaction inhibitors that perturbed the expression of a gene under the control of these Hippo pathway effectors." @default.
- W3035339434 created "2020-06-19" @default.
- W3035339434 creator A5004269320 @default.
- W3035339434 creator A5012574716 @default.
- W3035339434 creator A5013603239 @default.
- W3035339434 creator A5013789359 @default.
- W3035339434 creator A5015519778 @default.
- W3035339434 creator A5022246263 @default.
- W3035339434 creator A5022334369 @default.
- W3035339434 creator A5027834872 @default.
- W3035339434 creator A5032651337 @default.
- W3035339434 creator A5036560545 @default.
- W3035339434 creator A5041313428 @default.
- W3035339434 creator A5045643656 @default.
- W3035339434 creator A5050083666 @default.
- W3035339434 creator A5058231012 @default.
- W3035339434 creator A5061569562 @default.
- W3035339434 creator A5063201478 @default.
- W3035339434 creator A5066813728 @default.
- W3035339434 creator A5070067508 @default.
- W3035339434 creator A5074719719 @default.
- W3035339434 creator A5075610512 @default.
- W3035339434 creator A5083330306 @default.
- W3035339434 date "2020-07-15" @default.
- W3035339434 modified "2023-10-17" @default.
- W3035339434 title "TEAD–YAP Interaction Inhibitors and MDM2 Binders from DNA‐Encoded Indole‐Focused Ugi Peptidomimetics" @default.
- W3035339434 cites W1761618837 @default.
- W3035339434 cites W1944929196 @default.
- W3035339434 cites W1998063251 @default.
- W3035339434 cites W2003516462 @default.
- W3035339434 cites W2011121500 @default.
- W3035339434 cites W2041727766 @default.
- W3035339434 cites W2047613966 @default.
- W3035339434 cites W2051710717 @default.
- W3035339434 cites W2056169996 @default.
- W3035339434 cites W2062058167 @default.
- W3035339434 cites W2085341040 @default.
- W3035339434 cites W2098692163 @default.
- W3035339434 cites W2109939132 @default.
- W3035339434 cites W2112979860 @default.
- W3035339434 cites W2119923393 @default.
- W3035339434 cites W2127506367 @default.
- W3035339434 cites W2141588790 @default.
- W3035339434 cites W2261507005 @default.
- W3035339434 cites W2312660079 @default.
- W3035339434 cites W2480712017 @default.
- W3035339434 cites W2592265713 @default.
- W3035339434 cites W2600080366 @default.
- W3035339434 cites W2765540468 @default.
- W3035339434 cites W2777318060 @default.
- W3035339434 cites W2800542839 @default.
- W3035339434 cites W2900569176 @default.
- W3035339434 cites W2906608599 @default.
- W3035339434 cites W2909855854 @default.
- W3035339434 cites W2943492090 @default.
- W3035339434 cites W2944922217 @default.
- W3035339434 cites W2946065961 @default.
- W3035339434 cites W2949609112 @default.
- W3035339434 cites W2979876181 @default.
- W3035339434 cites W2990375069 @default.
- W3035339434 cites W2999977264 @default.
- W3035339434 cites W3035339434 @default.
- W3035339434 cites W4233471372 @default.
- W3035339434 cites W4241662468 @default.
- W3035339434 cites W4243260877 @default.
- W3035339434 doi "https://doi.org/10.1002/anie.202006280" @default.
- W3035339434 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7689693" @default.
- W3035339434 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32537835" @default.
- W3035339434 hasPublicationYear "2020" @default.
- W3035339434 type Work @default.
- W3035339434 sameAs 3035339434 @default.
- W3035339434 citedByCount "47" @default.
- W3035339434 countsByYear W30353394342020 @default.
- W3035339434 countsByYear W30353394342021 @default.
- W3035339434 countsByYear W30353394342022 @default.
- W3035339434 countsByYear W30353394342023 @default.
- W3035339434 crossrefType "journal-article" @default.
- W3035339434 hasAuthorship W3035339434A5004269320 @default.
- W3035339434 hasAuthorship W3035339434A5012574716 @default.
- W3035339434 hasAuthorship W3035339434A5013603239 @default.
- W3035339434 hasAuthorship W3035339434A5013789359 @default.
- W3035339434 hasAuthorship W3035339434A5015519778 @default.
- W3035339434 hasAuthorship W3035339434A5022246263 @default.
- W3035339434 hasAuthorship W3035339434A5022334369 @default.
- W3035339434 hasAuthorship W3035339434A5027834872 @default.
- W3035339434 hasAuthorship W3035339434A5032651337 @default.
- W3035339434 hasAuthorship W3035339434A5036560545 @default.
- W3035339434 hasAuthorship W3035339434A5041313428 @default.
- W3035339434 hasAuthorship W3035339434A5045643656 @default.
- W3035339434 hasAuthorship W3035339434A5050083666 @default.
- W3035339434 hasAuthorship W3035339434A5058231012 @default.
- W3035339434 hasAuthorship W3035339434A5061569562 @default.
- W3035339434 hasAuthorship W3035339434A5063201478 @default.
- W3035339434 hasAuthorship W3035339434A5066813728 @default.
- W3035339434 hasAuthorship W3035339434A5070067508 @default.
- W3035339434 hasAuthorship W3035339434A5074719719 @default.
- W3035339434 hasAuthorship W3035339434A5075610512 @default.
- W3035339434 hasAuthorship W3035339434A5083330306 @default.