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- W3035343412 abstract "Biologics for the treatment of inflammatory bowel disease (IBD) have been transformative to the therapeutic goals in the pediatric population. We review the biologics used to treat IBD, highlighting the importance of patient selection, dosing considerations, and therapeutic drug monitoring in children. Infliximab is well-established as a safe and efficacious therapy for Crohn’s disease and ulcerative colitis. Both dose escalation strategies and therapeutic drug monitoring increase the likelihood of response to anti-TNFα therapies. Early real-world experience of vedolizumab and ustekinumab in pediatric IBD shows promising results, including clinical response rates comparable to what is seen in adults, but there are limited data using them as first-line therapies. Biologic therapies have improved outcomes in pediatric IBD, including achieving mucosal healing as well as improved growth and pubertal development. Therapeutic drug monitoring improves likelihood of response to anti-TNFα therapies, but further studies for vedolizumab and ustekinumab are necessary." @default.
- W3035343412 created "2020-06-19" @default.
- W3035343412 creator A5017288280 @default.
- W3035343412 creator A5088916415 @default.
- W3035343412 date "2020-06-15" @default.
- W3035343412 modified "2023-10-18" @default.
- W3035343412 title "The Treatment of Pediatric Inflammatory Bowel Disease with Biologic Therapies" @default.
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- W3035343412 cites W2057220303 @default.
- W3035343412 cites W2075090387 @default.
- W3035343412 cites W2079295802 @default.
- W3035343412 cites W2084419767 @default.
- W3035343412 cites W2085491999 @default.
- W3035343412 cites W2087663450 @default.
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- W3035343412 cites W2144518079 @default.
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- W3035343412 cites W2171341132 @default.
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- W3035343412 cites W2324390810 @default.
- W3035343412 cites W2329755771 @default.
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- W3035343412 doi "https://doi.org/10.1007/s11894-020-00773-3" @default.
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