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• W3035352682 abstract "Fish gills are a structurally and functionally complex organ at the interface between organism and the aquatic environment. Gill functions include the transfer of organic molecules, both natural ones and xenobiotic compounds. Whether the branchial exchange of organic molecules involves active transporters is currently not known. Here, we investigated the presence, diversity, and functional activity of ATP-binding cassette (ABC) transporters in gills of juvenile rainbow trout. By means of RT-qPCR, gene transcripts of members from the abcb, abcc and abcg subfamilies were identified. Comparisons with mRNA profiles from trout liver and kidney revealed that ABC transporters known for an apical localization in polarized epithelia, especially abcc2 and abcb1 were underrepresented in the gills. In contrast, ABC transporters with mainly basolateral localization showed comparable gene transcript levels in the three organs. The most prominent ABC transporter in gills was an abcb subfamily member, which was annotated as abcb5 based on the synteny and phylogeny. Functional in vivo assays pointed to a role of branchial ABC transporters in branchial solute exchange. We further assessed the utility of primary gill cell cultures to characterize transporter-mediated branchial exchange of organic molecules, we examined ABC transporter gene transcript patterns and functional activity in primary cultures. The cultures display functional transport activity, but the ABC mRNA expression patterns were different to those of the intact gills. Overall, the findings of this study provide evidence for the presence of functional ABC transporter activity in gills of fish." @default.
• W3035352682 created "2020-06-19" @default.
• W3035352682 creator A5003870785 @default.
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• W3035352682 date "2020-01-01" @default.
• W3035352682 modified "2023-10-18" @default.
• W3035352682 title "ABC transporters in gills of rainbow trout (<i>Oncorhynchus mykiss</i>)" @default.
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• W3035352682 doi "https://doi.org/10.1242/jeb.221069" @default.
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• W3035352682 hasPublicationYear "2020" @default.
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