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• W3035355252 abstract "Two unsymmetrical dinucleotide phosphate triesters were synthesized via transesterification from tris(2,2,2-trifluoroethyl) phosphate. The protected triesters were phosphytilated to generate phosphoramidites for solid-phase oligonucleotide synthesis. Neutral phenylethyl phosphate-modified short-interfering RNAs (siRNAs) were synthesized and evaluated for their gene-silencing ability, siRNA strand selection, and resistance to nucleases. These backbone-modified phosphate triester siRNAs offer many improvements compared to natural unmodified siRNAs." @default.
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• W3035355252 date "2020-06-09" @default.
• W3035355252 modified "2023-10-18" @default.
• W3035355252 title "Synthesis and Evaluation of Neutral Phosphate Triester Backbone-Modified siRNAs" @default.
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• W3035355252 doi "https://doi.org/10.1021/acsmedchemlett.0c00232" @default.
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