Matches in SemOpenAlex for { <https://semopenalex.org/work/W3035355356> ?p ?o ?g. }
- W3035355356 abstract "ABSTRACT Enteropathogenic E. coli (EPEC) are recognized as one of the leading bacterial causes of infantile diarrhea worldwide. Weaned C57BL/6 mice pretreated with antibiotics were challenged orally with wild-type EPEC or escN mutant (lacking type 3 secretion system) to determine colonization, inflammatory responses and clinical outcomes during infection. Antibiotic disruption of intestinal microbiota enabled efficient colonization by wild-type EPEC resulting in growth impairment and diarrhea. Increase in inflammatory biomarkers, chemokines, cellular recruitment and pro-inflammatory cytokines were observed in intestinal tissues. Metabolomic changes were also observed in EPEC infected mice with changes in TCA cycle intermediates, increased creatine excretion and shifts in gut microbial metabolite levels. In addition, by 7 days after infection, although weights were recovering, EPEC-infected mice had increased intestinal permeability and decreased colonic claudin-1 levels. The escN mutant colonized the mice, but had no weight changes or increased inflammatory biomarkers, showing the importance of the T3SS in EPEC virulence in this model. In conclusion, a murine infection model treated with antibiotics has been developed to mimic many clinical outcomes seen in children with EPEC infection and to examine potential roles of selected virulence traits. This model can help in further understanding mechanisms involved in the pathogenesis of EPEC infections and potential outcomes and thus assist in the development of potential preventive or therapeutic interventions." @default.
- W3035355356 created "2020-06-19" @default.
- W3035355356 creator A5014885555 @default.
- W3035355356 creator A5015562901 @default.
- W3035355356 creator A5015959810 @default.
- W3035355356 creator A5022092920 @default.
- W3035355356 creator A5028707065 @default.
- W3035355356 creator A5034704040 @default.
- W3035355356 creator A5042262680 @default.
- W3035355356 creator A5045149586 @default.
- W3035355356 creator A5052096453 @default.
- W3035355356 creator A5071031273 @default.
- W3035355356 date "2020-06-12" @default.
- W3035355356 modified "2023-10-07" @default.
- W3035355356 title "EnteropathogenicEscherichia coli(EPEC) Infection Induces Diarrhea, Intestinal Damage, Metabolic Alterations and Increased Intestinal Permeability in a Murine Model" @default.
- W3035355356 cites W1573547148 @default.
- W3035355356 cites W1716725129 @default.
- W3035355356 cites W1803487872 @default.
- W3035355356 cites W1821981622 @default.
- W3035355356 cites W1856839109 @default.
- W3035355356 cites W1902385211 @default.
- W3035355356 cites W1938704217 @default.
- W3035355356 cites W1955491099 @default.
- W3035355356 cites W1966597734 @default.
- W3035355356 cites W1971769790 @default.
- W3035355356 cites W1974633080 @default.
- W3035355356 cites W1975057095 @default.
- W3035355356 cites W1980607288 @default.
- W3035355356 cites W1986843662 @default.
- W3035355356 cites W1987985249 @default.
- W3035355356 cites W1993182130 @default.
- W3035355356 cites W1998792609 @default.
- W3035355356 cites W2003362410 @default.
- W3035355356 cites W2007323774 @default.
- W3035355356 cites W2009762249 @default.
- W3035355356 cites W2010603109 @default.
- W3035355356 cites W2021369351 @default.
- W3035355356 cites W2023114517 @default.
- W3035355356 cites W2025132803 @default.
- W3035355356 cites W2029836902 @default.
- W3035355356 cites W2032183557 @default.
- W3035355356 cites W2033213146 @default.
- W3035355356 cites W2048882025 @default.
- W3035355356 cites W2066505654 @default.
- W3035355356 cites W2067303627 @default.
- W3035355356 cites W2069963356 @default.
- W3035355356 cites W2073376843 @default.
- W3035355356 cites W2078787530 @default.
- W3035355356 cites W2087855204 @default.
- W3035355356 cites W2096666146 @default.
- W3035355356 cites W2102907894 @default.
- W3035355356 cites W2107277218 @default.
- W3035355356 cites W2108707064 @default.
- W3035355356 cites W2114053580 @default.
- W3035355356 cites W2119874529 @default.
- W3035355356 cites W2120795945 @default.
- W3035355356 cites W2123056400 @default.
- W3035355356 cites W2124014948 @default.
- W3035355356 cites W2124309300 @default.
- W3035355356 cites W2124446505 @default.
- W3035355356 cites W2130393835 @default.
- W3035355356 cites W2135894069 @default.
- W3035355356 cites W2136512620 @default.
- W3035355356 cites W2140145998 @default.
- W3035355356 cites W2144629404 @default.
- W3035355356 cites W2147255761 @default.
- W3035355356 cites W2150069228 @default.
- W3035355356 cites W2150262463 @default.
- W3035355356 cites W2153029740 @default.
- W3035355356 cites W2161640738 @default.
- W3035355356 cites W2167567258 @default.
- W3035355356 cites W2171228833 @default.
- W3035355356 cites W2190558971 @default.
- W3035355356 cites W2346215072 @default.
- W3035355356 cites W2486949243 @default.
- W3035355356 cites W2511494454 @default.
- W3035355356 cites W2515189496 @default.
- W3035355356 cites W2525209951 @default.
- W3035355356 cites W2561064104 @default.
- W3035355356 cites W2592653282 @default.
- W3035355356 cites W2603840535 @default.
- W3035355356 cites W2731035140 @default.
- W3035355356 cites W2739115656 @default.
- W3035355356 cites W2756895691 @default.
- W3035355356 cites W2800727394 @default.
- W3035355356 cites W2802931548 @default.
- W3035355356 cites W2885093728 @default.
- W3035355356 cites W2888550839 @default.
- W3035355356 cites W2895269825 @default.
- W3035355356 cites W2912968892 @default.
- W3035355356 cites W2949659481 @default.
- W3035355356 cites W2967593931 @default.
- W3035355356 doi "https://doi.org/10.1101/2020.06.12.148593" @default.
- W3035355356 hasPublicationYear "2020" @default.
- W3035355356 type Work @default.
- W3035355356 sameAs 3035355356 @default.
- W3035355356 citedByCount "2" @default.
- W3035355356 countsByYear W30353553562020 @default.
- W3035355356 crossrefType "posted-content" @default.
- W3035355356 hasAuthorship W3035355356A5014885555 @default.