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- W3035398972 abstract "• Mitochondrial oxidative stress is critical for Chagas heart disease pathogenesis. • We tested the natural biphenyl honokiol as antioxidant therapy for Chagas cardiomyopathy. • Honokiol activates mitochondrial antioxidant enzymes via AMPK/NFE2L2/SIRT3 signaling. • Honokiol treatment of chronically infected mice decreases cardiac oxidative damage. • Honokiol shows therapeutic potential for treatment of chronic Chagas heart disease." @default.
- W3035398972 created "2020-06-19" @default.
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- W3035398972 date "2020-08-01" @default.
- W3035398972 modified "2023-10-09" @default.
- W3035398972 title "Honokiol attenuates oxidative stress-dependent heart dysfunction in chronic Chagas disease by targeting AMPK / NFE2L2 / SIRT3 signaling pathway" @default.
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- W3035398972 doi "https://doi.org/10.1016/j.freeradbiomed.2020.05.024" @default.
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