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- W3035438713 abstract "Bu çalışmada, yeni 1,2,3-triazol bileşiklerinin (4 ve 5) sentezi, karakterizasyonu, ksantin oksidaz enzimi üzerine in vitro inhibisyon etkilerinin incelenmesi ve moleküler doking çalışmaları gerçekleştirildi. Bu amaçla öncelikle; hedef ürünler (4 ve 5), bütadien sülfondan çıkılarak çeşitli kimyasal transformasyonlarla sentezlendi. Sentezlenen bütün bileşiklerin yapıları spektroskopik yöntemlerle aydınlatıldı. İkinci aşamada; 4 ve 5 bileşiklerinin ksantin oksidaz enzimi üzerine in vitro inhibisyon etkileri incelendi. Enzim inhibisyon sonuçlarına göre; 4 (IC50 = 0.609 µM) ve 5 (IC50 = 0.901 µM) bileşiklerinin, ksantin oksidaz enzim inhibisyonu için ilaç olarak kullanılan Allopurinol’den (IC50 = 1.143 µM) daha güçlü inhibisyon etki gösterdiği tespit edildi. Son olarak; 4 ve 5 bileşiklerinin, ksantin oksidaz eziminin (PDB ID:3NVY) aktif kısmına bağlanma modları, moleküler doking çalışmaları ile açıklandı." @default.
- W3035438713 created "2020-06-19" @default.
- W3035438713 creator A5029911766 @default.
- W3035438713 date "2020-06-15" @default.
- W3035438713 modified "2023-09-27" @default.
- W3035438713 title "Ksantin Oksidaz İnhibitörü Yeni 1,2,3-triazol Türevlerinin Sentezi, Karakterizasyonu ve Moleküler Doking Çalışmaları" @default.
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- W3035438713 doi "https://doi.org/10.17798/bitlisfen.644565" @default.
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