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• W3035504704 endingPage "102264" @default.
• W3035504704 startingPage "102264" @default.
• W3035504704 abstract "Multiple sclerosis (MS) is an inflammatory autoimmune disease characterized by neurodegeneration in the CNS. Interferon-beta (IFN-β) is an FDA-approved drug used as the first-line treatment for relapse-remitting multiple sclerosis (RRMS). The exact mechanism of IFN-β during the treatment of RRMS still remains unknown. Recently, many studies have shifted towards the role of miRNAs in the treatment of MS patients.Herein, the expression level of miR-185-5p and miR-320a has been evaluated in order to candidate them as novel biomarkers for monitoring the response to IFN-β therapy. For this purpose, one-hundred whole blood samples from patients with RRMS were collected, consisting of 50 responders and 50 non-responders to IFN-β therapy. To predict the possible molecular mechanisms of IFN-β and highlight the role of these miRNAs, in silico analysis was applied to enrich the signaling pathways which may be involved based on the target genes of miR-185-5p and miR-320a.It is identified that the differentially expressed miR-185-5p was statistically significant between the two treated groups with IFN-β. Furthermore, MAPK signaling pathway was suggested as the main non-canonical pathway involved in IFN-β therapy.miR-185-5p could be considered as a novel biomarker for monitoring the response to IFN-β therapy." @default.
• W3035504704 created "2020-06-19" @default.
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• W3035504704 date "2020-09-01" @default.
• W3035504704 modified "2023-10-17" @default.
• W3035504704 title "Connection of miR-185 and miR-320a expression levels with response to interferon-beta in multiple sclerosis patients" @default.
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• W3035504704 doi "https://doi.org/10.1016/j.msard.2020.102264" @default.
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