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• W3035506789 abstract "Abstract Balancing the relative growth of body and organs is of key importance for coordinating size and function. This is of particular relevance in post-embryonically growing organisms, facing this challenge life-long. We addressed this question in the neuroretina of medaka fish (Oryzias latipes), where growth and size regulation are crucial for functional homeostasis of the visual system. We find that a central growth regulator, Igf1 receptor, is necessary and sufficient for proliferation control in the postembryonic retinal stem cell niche, the ciliary marginal zone (CMZ). Targeted activation of Igf1r signalling in the CMZ uncouples neuroretina growth from body size control, increasing layer thickness while preserving the structural integrity of the retina. The retinal expansion is driven exclusively by enhanced proliferation of progenitor cells while stem cells do not respond to Igf1r modulation. Our findings position Igf signalling as key module controlling retinal size and structure with far reaching evolutionary implications." @default.
• W3035506789 created "2020-06-19" @default.
• W3035506789 creator A5010305887 @default.
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• W3035506789 date "2020-06-10" @default.
• W3035506789 modified "2023-09-26" @default.
• W3035506789 title "Igf signalling uncouples retina growth from body size by modulating progenitor cell division" @default.
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• W3035506789 doi "https://doi.org/10.1101/2020.06.10.144360" @default.
• W3035506789 hasPublicationYear "2020" @default.
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