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- W3035519997 abstract "Abstract Cell death events continuously challenge epithelial barrier function, yet are crucial to eliminate old or critically damaged cells. How such apoptotic events are spatio-temporally organized to maintain epithelial homeostasis remains unclear. We observe waves of Extracellular Signal-Regulated Kinase (ERK) and AKT serine/threonine kinase (Akt) activity pulses that originate from apoptotic cells and propagate radially to healthy surrounding cells. This requires Epidermal Growth Factor Receptor (EGFR) and matrix metalloproteinase (MMP) signaling. At the single-cell level, ERK/Akt waves act as spatial survival signals that locally protect cells in the vicinity of the epithelial injury from apoptosis for a period of 3-4h. At the cell population level, ERK/Akt waves maintain epithelial homeostasis (EH) in response to mild or intense environmental insults. Disruption of this spatial signaling system results in the inability of a model epithelial tissue to ensure barrier function in response to environmental insults." @default.
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- W3035519997 date "2020-06-11" @default.
- W3035519997 modified "2023-10-18" @default.
- W3035519997 title "Collective ERK/Akt activity waves orchestrate epithelial homeostasis by driving apoptosis-induced survival" @default.
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- W3035519997 doi "https://doi.org/10.1101/2020.06.11.145573" @default.
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