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• W3035548321 abstract "Abstract Background Respiratory syncytial virus (RSV) infection is implicated in subsequent development of asthma/wheezing (AW) among term and pre‐term infants. We describe the cumulative incidence of AW among hospitalized and ambulatory neonates/infants/toddlers following RSV infection diagnosis over three independent follow‐up periods. Methods Between January 1, 2007 and March 31, 2016, patients aged 0‐2 years old with first clinical diagnosis of RSV infection were identified using the Optum ® integrated electronic health records and claims database. Patients diagnosed with AW ≤ 30 days post‐RSV diagnosis were excluded. Three cohorts with 1, 3, and 5 years of follow‐up were stratified by presence or absence of specific RSV high‐risk factors, including pre‐term birth and pre‐defined, pre‐existing comorbidities. Descriptive statistics and logistic regression results were reported. Results Overall, 9811, 4524, and 1788 RSV‐infected high‐risk factor negative patients were included in 1, 3, and 5‐year independent cohorts, respectively. Of these, 6.5%, 6.9%, and 5.8%, respectively had RSV‐related hospitalization. By the end of follow‐up, 14.9%, 28.2%, and 36.3% had AW events. Overall, 3030, 1378, and 552 RSV‐infected high‐risk factor positive patients were included in the respective cohorts. Of these, 11.4%, 11.1%, and 11.6%, respectively were hospitalized with initial RSV infection and 18.1%, 32.9%, and 37.9% had subsequent AW events within the follow‐up period. Logistic regression confirmed RSV‐related hospitalization significantly increased the likelihood of developing AW ( P < .05) in high‐risk factor positive and negative patients. Conclusions In infants diagnosed with RSV infection, RSV‐related hospitalization was associated with a significantly increased likelihood of AW development for at least 5 years, compared with non‐hospitalized patients." @default.
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• W3035548321 date "2020-06-12" @default.
• W3035548321 modified "2023-10-05" @default.
• W3035548321 title "Cumulative incidence of post‐infection asthma or wheezing among young children clinically diagnosed with respiratory syncytial virus infection in the United States: A retrospective database analysis" @default.
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• W3035548321 doi "https://doi.org/10.1111/irv.12770" @default.
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