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- W3035563458 abstract "Reciprocal neuron-glia cell communication is fundamental for the proper function of the nervous system. Oligodendrocytes are the myelinating cells of the central nervous system (CNS) that insulate and provide trophic support to neurons. This effective interaction is crucial not only for myelination but also for long-term axonal survival and neural connectivity. In recent years, exosomes have been portrayed as key players in intercellular interaction in the context of the healthy and diseased CNS. They act as communicating vehicles, true attachés operating between neurons and glial cells. Despite the complex exosome circuitry within the nervous system, experimental evidence supports the role of exosomes in modulating myelination. Oligodendrocytes secrete exosomes in response to neuronal signals in an electric activity-dependent manner. These released exosomes are then internalized by neurons, contributing to their integrity and activity. In turn, neurons secrete exosomes to control the communication between them and with myelinating cells in order to regulate synaptic function in neuronal development, myelin maintenance, and neuroregeneration. In this review, we provide a critical view of the current understanding on how exosomes, either from CNS-resident cells or from the periphery, contribute to the formation and maintenance of myelin and, additionally, on how the differential content of exosomes in normal and pathological conditions foresees the use of these nanovesicles as putative diagnostic and/or therapeutical agents in white matter degeneration-associated diseases." @default.
- W3035563458 created "2020-06-19" @default.
- W3035563458 creator A5014600161 @default.
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- W3035563458 creator A5039274663 @default.
- W3035563458 creator A5072357593 @default.
- W3035563458 creator A5076580222 @default.
- W3035563458 date "2020-06-16" @default.
- W3035563458 modified "2023-10-01" @default.
- W3035563458 title "Exosome Circuitry During (De)(Re)Myelination of the Central Nervous System" @default.
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- W3035563458 doi "https://doi.org/10.3389/fcell.2020.00483" @default.
- W3035563458 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7308472" @default.
- W3035563458 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32612996" @default.