FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3035580034> ?p ?o ?g. }

• W3035580034 endingPage "466.e9" @default.
• W3035580034 startingPage "466.e1" @default.
• W3035580034 abstract "Introduction and objective Reliable urinary biomarker proteins would be invaluable in identifying children with ureteropelvic junction obstruction (UPJO) as the existing biomarker proteins are inconsistent in their predictive ability. Therefore, the aim of this study was to identify consistent and reliable urinary biomarker proteins in children with UPJO. Methods To identify candidate biomarker proteins, total protein from age-restricted (<2 years) and sex-matched (males) control (n = 22) and UPJO (n = 21) urine samples was analyzed by mass spectrometry. Proteins that were preferentially identified in UPJO samples were selected (2-step process) and ranked according to their diagnostic odds ratio value. The top ten proteins with highest odds ratio values were selected and tested individually by ELISA. The total amount of each protein was normalized to urine creatinine and the median with interquartile ranges for control and UPJO samples was determined. Additionally, fold change (UPJO/Control) of medians of the final panel of 5 proteins was also determined. Finally, we calculated the average + 3(SD) and average + 4(SD) values of each of the 5 proteins in the control samples and used it as an arbitrary cutoff to classify individual control and UPJO samples. Results In the first step of our selection process, we identified 171 proteins in UPJO samples that were not detected in the majority of the control samples (16/22 samples, or 72.7%). Of the 171 proteins, only 50 proteins were detected in at least 11/21 (52.4%) of the UPJO samples and hence were selected in the second step. Subsequently, these 50 proteins were ranked according to the odds ratio value and the top 10 ranked proteins were validated by ELISA. Five of the 10 proteins – prostaglandin-reductase-1, ficolin-2, nicotinate-nucleotide pyrophosphorylase [carboxylating], immunoglobulin superfamily-containing leucine-rich-repeat-protein and vascular cell adhesion molecule-1 were present at higher levels in the UPJO samples (fold-change of the median protein concentrations ranging from 2.9 to 9.4) and emerged as a panel of biomarkers to identify obstructive uropathy. Finally, the order of prevalence of the 5 proteins in UPJO samples is PTGR1>FCN2>QPRT>ISLR>VCAM1. Conclusion Graphical AbstractPTGR1, FCN2, QPRT, ISLR and VCAM1 form a panel of UPJO-inherent urinary biomarker proteins. (A) Normalized PTGR1, FCN2, QPRT, ISLR and VCAM1 amounts in control and UPJO samples. (B) Fold change (UPJO/control) of medians of normalized PTGR1, FCN2, QPRT, ISLR and VCAM1 amounts. View Large Image Figure Viewer Download Hi-res image" @default.
• W3035580034 created "2020-06-19" @default.
• W3035580034 creator A5019700548 @default.
• W3035580034 creator A5040029066 @default.
• W3035580034 creator A5046441111 @default.
• W3035580034 creator A5048926954 @default.
• W3035580034 creator A5049653553 @default.
• W3035580034 creator A5053724877 @default.
• W3035580034 creator A5072942205 @default.
• W3035580034 creator A5084984818 @default.
• W3035580034 date "2020-08-01" @default.
• W3035580034 modified "2023-09-25" @default.
• W3035580034 title "A novel urinary biomarker protein panel to identify children with ureteropelvic junction obstruction – A pilot study" @default.
• W3035580034 cites W1922006896 @default.
• W3035580034 cites W1964485266 @default.
• W3035580034 cites W1990305857 @default.
• W3035580034 cites W1997088049 @default.
• W3035580034 cites W2003521069 @default.
• W3035580034 cites W2004638606 @default.
• W3035580034 cites W2034305484 @default.
• W3035580034 cites W2050703007 @default.
• W3035580034 cites W2051608764 @default.
• W3035580034 cites W2054046167 @default.
• W3035580034 cites W2056094992 @default.
• W3035580034 cites W2067197207 @default.
• W3035580034 cites W2075911589 @default.
• W3035580034 cites W2077587096 @default.
• W3035580034 cites W2080752012 @default.
• W3035580034 cites W2082820065 @default.
• W3035580034 cites W2102094290 @default.
• W3035580034 cites W2108601290 @default.
• W3035580034 cites W2135368442 @default.
• W3035580034 cites W2182402067 @default.
• W3035580034 cites W2182634867 @default.
• W3035580034 cites W2301008481 @default.
• W3035580034 cites W2317764313 @default.
• W3035580034 cites W2344325779 @default.
• W3035580034 cites W2366419812 @default.
• W3035580034 cites W2395632397 @default.
• W3035580034 cites W2553978018 @default.
• W3035580034 cites W2763465034 @default.
• W3035580034 cites W2794984548 @default.
• W3035580034 cites W2887579551 @default.
• W3035580034 cites W2980298322 @default.
• W3035580034 cites W2989152607 @default.
• W3035580034 doi "https://doi.org/10.1016/j.jpurol.2020.05.163" @default.
• W3035580034 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7529974" @default.
• W3035580034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32620509" @default.
• W3035580034 hasPublicationYear "2020" @default.
• W3035580034 type Work @default.
• W3035580034 sameAs 3035580034 @default.
• W3035580034 citedByCount "9" @default.
• W3035580034 countsByYear W30355800342021 @default.
• W3035580034 countsByYear W30355800342022 @default.
• W3035580034 countsByYear W30355800342023 @default.
• W3035580034 crossrefType "journal-article" @default.
• W3035580034 hasAuthorship W3035580034A5019700548 @default.
• W3035580034 hasAuthorship W3035580034A5040029066 @default.
• W3035580034 hasAuthorship W3035580034A5046441111 @default.
• W3035580034 hasAuthorship W3035580034A5048926954 @default.
• W3035580034 hasAuthorship W3035580034A5049653553 @default.
• W3035580034 hasAuthorship W3035580034A5053724877 @default.
• W3035580034 hasAuthorship W3035580034A5072942205 @default.
• W3035580034 hasAuthorship W3035580034A5084984818 @default.
• W3035580034 hasBestOaLocation W30355800342 @default.
• W3035580034 hasConcept C119060515 @default.
• W3035580034 hasConcept C126322002 @default.
• W3035580034 hasConcept C126894567 @default.
• W3035580034 hasConcept C156957248 @default.
• W3035580034 hasConcept C2780026642 @default.
• W3035580034 hasConcept C2781197716 @default.
• W3035580034 hasConcept C54355233 @default.
• W3035580034 hasConcept C60644358 @default.
• W3035580034 hasConcept C71924100 @default.
• W3035580034 hasConcept C77411442 @default.
• W3035580034 hasConcept C86803240 @default.
• W3035580034 hasConceptScore W3035580034C119060515 @default.
• W3035580034 hasConceptScore W3035580034C126322002 @default.
• W3035580034 hasConceptScore W3035580034C126894567 @default.
• W3035580034 hasConceptScore W3035580034C156957248 @default.
• W3035580034 hasConceptScore W3035580034C2780026642 @default.
• W3035580034 hasConceptScore W3035580034C2781197716 @default.
• W3035580034 hasConceptScore W3035580034C54355233 @default.
• W3035580034 hasConceptScore W3035580034C60644358 @default.
• W3035580034 hasConceptScore W3035580034C71924100 @default.
• W3035580034 hasConceptScore W3035580034C77411442 @default.
• W3035580034 hasConceptScore W3035580034C86803240 @default.
• W3035580034 hasFunder F4320337338 @default.
• W3035580034 hasIssue "4" @default.
• W3035580034 hasLocation W30355800341 @default.
• W3035580034 hasLocation W30355800342 @default.
• W3035580034 hasOpenAccess W3035580034 @default.
• W3035580034 hasPrimaryLocation W30355800341 @default.
• W3035580034 hasRelatedWork W2013508761 @default.
• W3035580034 hasRelatedWork W2025722779 @default.
• W3035580034 hasRelatedWork W2061253854 @default.
• W3035580034 hasRelatedWork W2089449606 @default.
• W3035580034 hasRelatedWork W2232523475 @default.

• next